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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 02

Page:

356-363

Research Field:

Publishing date:

Info

Title:

Research progress of the mechanism of action of circular RNA in glioma

Author(s):

LIU Yi; SHEN Chenfu

Department of Neurosurgery,Xiangya Hospital,Central South University£¬Hunan Changsha 410000,China.

Keywords:

circular RNA; glioma; tumor markers; clinical prognosis

PACS:

R730

DOI:

10.3969/j.issn.1672-4992.2024.02.029

Abstract:

The prognosis of glioma is still poor after standard surgery,radiotherapy and chemotherapy,and the 5-year overall survival rate of glioblastoma is less than 10%.There is an urgent need to find new treatments to improve the prognosis.In recent years,studies on circRNA have found that circRNAs are differentially expressed in gliomas,which regulate the occurrence,proliferation and invasion of gliomas and may become a potential marker for the diagnosis of gliomas.In addition,some circRNAs are related to the stage of glioma,which may be helpful to judge the prognosis.Based on the stability and high conservation of circRNAs,we believe that circRNAs may have a molecular target for the treatment of gliomas.This article reviews the research progress on the role of circRNAs in glioma in recent years,discusses the potential value and role of circRNAs in glioma,and provides a potential treatment direction for future treatment.

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