|Table of Contents|

Research progress of pyroptosis and mechanism in tumor radiotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 02
Page:
351-355
Research Field:
Publishing date:

Info

Title:
Research progress of pyroptosis and mechanism in tumor radiotherapy
Author(s):
LI Dongdong1; WANG Chengzhi1; ZHANG Xiaoqing2; LIU Peimin1
1.The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450002,China;2.The First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052,China.
Keywords:
pyroptosis; malignant tumor; radiotherapy; research progress
PACS:
R730.55
DOI:
10.3969/j.issn.1672-4992.2024.02.028
Abstract:
Pyroptosis is a new type of cell death,which has bidirectionally modulatory effect in tumor.On the one hand,pyroptosis promotes cancer cell death,inhibit tumor cell proliferation,enhance radiochemotherapy sensitivity,and improve anti-tumor immunity.On the other hand,radiation therapy is an important means of malignant tumor treatment,pyroptosis induces radiation inflammatory damage and affects the efficacy of radiotherapy,however,the potential mechanism of pyroptosis in radiotherapy has not been fully clarified.This article summarizes the mechanism of pyroptosis in anti-tumor therapy and the dual role of pyroptosis in radiotherapy,and looks forward to the application and dilemma of pyroptosis in radiotherapy,discusses the feasibility of targeting pyroptosis to improve radiotherapy efficacy and reduce radiation damage,hoping to provide a reference for the follow-up mechanism research of radiotherapy,and provide a new direction for the research of radiotherapy targeting pyroptosis.

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Memo

Memo:
National Natural Science Foundation of China(No.82204981）；国家自然科学基金(编号：82204981)；国家中医临床研究基地科研专项(编号：2021JDZX2002)；河南省特色骨干学科中医学学科建设项目(编号：STG-ZYX06-202145)；河南中医药大学博士科研基金项目（编号：2022BSJJ08）
Last Update: 1900-01-01