|Table of Contents|

Clinical features of children with primary malignant non-Wilms renal tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 04
Page:
702-706
Research Field:
Publishing date:

Info

Title:
Clinical features of children with primary malignant non-Wilms renal tumors
Author(s):
JIAO Yangyang; FU Pan; YANG Jingwei; JIANG Shayi; LIAO Xuelian; SHAO Jingbo
Department of Hematology and Oncology,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China.
Keywords:
child; renal tumors; non-Wilms; prognosis
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2023.04.021
Abstract:
Objective:To investigate the clinical features and prognosis of primary non-Wilms renal tumors in children.Methods:A retrospective analysis was performed on 22 cases with primary non-Wilms renal tumors in department of hematology and oncology of Shanghai Children's Hospital from January 2015 to December 2020.Results:Totally 22 patients were included in the study,including 12 males and 10 females,with a median age of 42.5 months (4~173 months).10 cases were clear cell sarcoma.5 cases were malignant rhabdoid tumor.4 cases were renal cell carcinoma.2 cases were neuroblastoma and 1 case was ewings sarcoma.The common clinical manifestations were hematuresis and mass found in physical examination.2 cases were in stage I,3 cases in stage II,11 cases in stage III,and 6 cases in stage IV.Radical tumor resection was performed on 21 patients.The median follow-up time was 23 months(4~80 months).The 2-year and 5-year OS rate were 81.3% and 69.7% respectively.The OS rate of stage IV was lower than stage I+II+III and the difference was statistically significant.Conclusion:The primary non-Wilms renal tumors are rare.Immunohistochemistry and molecular diagnostic approaches are of considerable importance to establish a precise diagnosis.Stage IV is associated with poor prognosis.Early detection,diagnosis and treatment of early multidisciplinary can help improve prognosis.

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上海市科委自然科学基金项目（编号：19ZR1442400）
Last Update: 1900-01-01