|Table of Contents|

The expressions and clinical significance of E-cadherin in gastric adenocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 04
Page:
698-701
Research Field:
Publishing date:

Info

Title:
The expressions and clinical significance of E-cadherin in gastric adenocarcinoma
Author(s):
GUO XiaoxiongZHONG CanmeiCHEN Fenglin
Department of Gastroenterology,Fujian Medical University Union Hospital,Fujian Fuzhou 350001,China.
Keywords:
gastric adenocarcinomaE-cadherinimmunohistochemicallyautomated digital image analysis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2023.04.020
Abstract:
Objective:To elucidate the expression of E-cadherin and its clinical significance in the gastric adenocarcinoma.Methods:A total of 61 gastric adenocarcinoma and adjacent normal tissues paraffin embedded tissues specimens and clinical factors were collected in our hospital.The expression of E-cadherin in gastric adenocarcinoma and adjacent normal tissues was determined by Immunohistochemically (IHC).IHC result was performed using automated digital image analysis by Image-Pro Plus 6.0 image analysis software.The association of E-cadherin expressions with the patients' clinicopathological features was investigated.Results:The expression of E-cadherin was significantly downregulation in gastric adenocarcinoma (P<0.01).The value of E-cadherin downregulated was significantly correlated with TNM stages (P<0.05),differentiation (P<0.05) and tumor invasion depth (P<0.05),and not related with gender,age,tumor size and lymphatic metastasis (P>0.05).Conclusion:In gastric adenocarcinoma,E-cadherin was downregulated,which indicated that E-cadherin may play a role in the carcinogenesis,invasion of the gastric adenocarcinoma.

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Memo

Memo:
福建省临床医学重点专科资助项目(编号:闽卫科教[2012]149号);福建医科大学启航基金项目(编号:2020QH1098)
Last Update: 1900-01-01