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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 01

Page:

188-191

Research Field:

Publishing date:

Info

Title:

The role of neutrophil extracellular traps in the occurrence and development of hematological disease

Author(s):

ZOU Xindi; LI Xiaoxia

Department of Hematology,the First Affiliated Hospital of Harbin Medical University£¬Heilongjiang Harbin 150001£¬China.

Keywords:

neutrophils; neutrophil extracellular traps; hematological disease; pro-tumor effect; anti-inflammatory effect

PACS:

R733

DOI:

10.3969/j.issn.1672-4992.2023.01.036

Abstract:

Neutrophils are the first line of defense of the host's immune defense response.They kill pathogens through phagocytosis and degranulation to exert antibacterial effects.Neutrophil extracellular traps(NETs) are another mechanism for neutrophils to exert antibacterial effects discovered in recent years.However,more and more studies have proved that neutrophil extracellular traps are involved in the pathogenesis of many diseases,including inflammatory diseases and a variety of malignant tumors,among which the occurrence and development of hematological disease are closely related to the abnormal increase of NETs.At the same time,inhibiting the generation of NETs can alleviate tumor growth and inhibit its progression.

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Last Update: 2022-11-30