|Table of Contents|

Research progress on the application of Daratumumab in the treatment of hematological diseases and its drug resistance mechanism

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
192-196
Research Field:
Publishing date:

Info

Title:
Research progress on the application of Daratumumab in the treatment of hematological diseases and its drug resistance mechanism
Author(s):
LI Zhuanli12SHI Yajun2BAI Hai2
1.The First Clinical Medical College of Gansu University of Chinese Medicine,Gansu Lanzhou 730000,China;2.The 940th Hospital of Joint Logistic Support Force of PLA,Gansu Lanzhou 730050,China.
Keywords:
Daratumumabmultiple myelomaamyloidosisresistance mechanism
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2023.01.037
Abstract:
Daratumumab is the first generation of anti-CD38 monoclonal antibody,which has immunomodulatory,antibody-dependent cell-mediated cytotoxicity,antibody-dependent phagocytosis,and complement-dependent cytotoxicity.In recent years,there have been many studies and applications of anti-CD38 monoclonal antibodies in hematological diseases.The purpose of this review is to review the application of Daratumumab in the treatment of refractory relapsed multiple myeloma,newly diagnosed multiple myeloma,systemic amyloidosis,monoclonal gamma globulinosis with renal significance and the latest research progress in the mechanism of drug resistance.

References:

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Last Update: 2022-11-30