|Table of Contents|

Research progress of N6-methyladenine modification in the occurrence, development and treatment of malignant tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
183-187
Research Field:
Publishing date:

Info

Title:
Research progress of N6-methyladenine modification in the occurrence, development and treatment of malignant tumors
Author(s):
GUI Jiawei; XIAO Hui
Department of Otolaryngology Head and Neck Surgery，the Second Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150081，China.
Keywords:
N6-methyladenosine(m6A); epigenetics; cancer; target
PACS:
R73
DOI:
10.3969/j.issn.1672-4992.2023.01.035
Abstract:
In recent years,RNA modifications are gaining the interest of biologist worldwide.Till date,more than 170 modifications has been reported.Among these types，N6-methyladenosine(m6A) modification is the predominant mRNA modification,which regulates RNA splicing,translocation,stability and translation.m6A modification plays critical roles in the growth,differentiation and metabolism of cells.As a dynamic and reversible modification,the level of m6A is regulated by RNA methyltransferases,demethylases and m6A-binding proteins.More and more researches have implicated the correlation between m6A modification and human cancers.In this review,we summarize the research progress of m6A abnormal modification in the occurrence, development and treatment of various malignant tumors,in order to provide a new thought in anti-cancer therapy.

References:

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Last Update: 2022-11-30