|Table of Contents|

The research on the mechanism of tumor metastasis based on Ezrin protein

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 03
Page:
538-543
Research Field:
Publishing date:

Info

Title:
The research on the mechanism of tumor metastasis based on Ezrin protein
Author(s):
YANG YeCHU FuhaoDU ShihaoLI TaoBO RongqiangDING Xia
Beijing University of Chinese Medicine,Beijing 100102,China.
Keywords:
EzrinERMcytoskeleton proteintumor metastasis
PACS:
R73-37
DOI:
10.3969/j.issn.1672-4992.2022.03.034
Abstract:
Tumor metastasis is the main cause of tumor deterioration and death.In recent years,it has been found that many microRNAs(miRs),protein molecules,cell signal transduction pathways can mediate tumor migration and invasion.Ezrin protein,also known as cell chorionic protein,is a first discovered member of Ezrin/Radixin/Moesin(ERM)family,which is widely distributed in human cells.It is a connecting protein between cytoskeleton and cell membrane,participating in many complex cell life activities.Ezrin,as a hot molecule in tumor metastasis research in recent years,can affect the movement of tumor cells through different mechanisms,including promote the reassembly of actin and vesicular endocytosis between tumor cells.It affects not only a certain stage of tumor cell metastasis,but also different tumors and different stages of tumor metastasis through various ways.Therefore,Ezrin is an important molecule in the process of tumor development and an innovative target of tumor diagnosis and treatment.In this paper,the biological structure and function of Ezrin were briefly introduced,and the influence of Ezrin on various tumor cell metastasis was summarized.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.81630080);国家自然科学基金重点项目(编号:81630080)
Last Update: 2021-12-31