|Table of Contents|

Effect of tumor-associated macrophages on clinical prognosis and treatment of malignant tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 03
Page:
535-538
Research Field:
Publishing date:

Info

Title:
Effect of tumor-associated macrophages on clinical prognosis and treatment of malignant tumors
Author(s):
ZHU WentingCHEN Yan
Department of Oncology,the First Affiliated Hospital of Air Force Military Medical University,Shaanxi Xi'an 710032,China.
Keywords:
TAMsTMEchemotherapyimmunotherapy
PACS:
R730.51
DOI:
10.3969/j.issn.1672-4992.2022.03.033
Abstract:
As the core regulator in the tumor microenvironment(TME),tumor-associated macrophages(TAMs)play important roles in the initiation and progressionof malignancies.Activatedmacrophages could be polarized into M1 and M2 phenotype with different activation states and biological functions.In general,M1macrophages foster inflammation response against tumor cells,whereas M2 macrophagestend to exert an immune suppressive phenotype,favoring tumor progression.M1/M2 macrophages could be re-educatedto each other under different TME.Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer,so it is necessary explore the impact of TAMs on the clinical prognosis and treatment of malignant tumors.This article reviewed the relationship between TAMs and the clinical prognosis of malignant tumors,and the interaction between TAMs and tumor chemotherapy and immunotherapy.

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Memo

Memo:
National Natural Science Foundation of China(No.81872265);国家自然科学基金面上项目(编号:81872265)
Last Update: 2021-12-31