|Table of Contents|

The state and progress of research on diagnosis and treatment of HPV-associated oropharyngeal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 03
Page:
544-547
Research Field:
Publishing date:

Info

Title:
The state and progress of research on diagnosis and treatment of HPV-associated oropharyngeal cancer
Author(s):
ZHU RunqiuZHU Huiyong
Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang Hangzhou 310003,China.
Keywords:
human papillomavirus(HPV)oropharyngeal squamous cell carcinomabiomarkerstherapyprognosis
PACS:
R739.8
DOI:
10.3969/j.issn.1672-4992.2022.03.035
Abstract:
Human papillomavirus infection can cause a variety of diseases,among which high-risk human papillomavirus and head and neck squamous cell carcinoma are more closely related to cervical cancer.In recent years,a large number of studies have confirmed that the incidence of oropharyngeal carcinoma is increasing year by year,among which the associated oropharyngeal squamous cell carcinomas caused by human papillomavirus infection is more significant.This article aims to review current status of clinical management of HPV-associated oropharyngeal cancer in recent years and to summarize progress in relevant research,in order to provide scientific basis for the diagnosis,prevention and treatment of HPV-associated oropharyngeal cancer in the future.

References:

[1] CARLANDER AF,GRONHOJ LC,JENSEN DH,et al.Continuing rise in oropharyngeal cancer in a high HPV prevalence area:A Danish population-based study from 2011 to 2014[J].Eur J Cancer,2017,70:75-82.
[2] TABERNA M,MENA M,PAVON MA,et al.Human papillomavirus-related oropharyngeal cancer[J].Ann Oncol,2017,28(10):2386-2398.
[3] BRAVO IG,FELEZ-SANCHEZ M.Papillomaviruses:Viral evolution,cancer and evolutionary medicine[J].Evol Med Public Health,2015,2015(1):32-51.
[4] OROSZ E,GOMBOS K,PETREVSZKY N,et al.Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas:combined genomic and radiology based 3D model[J].Sci Rep,2020,10(1):40.
[5] VOJTECHOVA Z,ZAVADIL J,KLOZAR J,et al.Comparison of the miRNA expression profiles in fresh frozen and formalin-fixed paraffin-embedded tonsillar tumors[J].PLoS One,2017,12(6):e179645.
[6] WURLITZER M,MOECKELMANN N,KRIEGS M,et al.Mass spectrometric comparison of HPV-positive and HPV-negative oropharyngeal cancer[J].Cancers,2020,12(6):1531.
[7] D'SOUZA G,MCNEEL TS,FAKHRY C.Understanding personal risk of oropharyngeal cancer:risk-groups for oncogenic oral HPV infection and oropharyngeal cancer[J].Ann Oncol,2017,28(12):3065-3069.
[8] ANANTHARAMAN D,ABEDI-ARDEKANI B,BEACHLER DC,et al.Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer[J].Int J Cancer,2017,140(9):1968-1975.
[9] JEMAL A,SIMARD EP,DORELL C,et al.Annual report to the nation on the status of cancer,1975-2009,featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels[J].J Natl Cancer Inst,2013,105(3):175-201.
[10] TIMBANG MR,SIM MW,BEWLEY AF,et al.HPV-related oropharyngeal cancer:a review on burden of the disease and opportunities for prevention and early detection[J].Hum Vaccin Immunother,2019,15(7-8):1920-1928.
[11] LIU J,YANG XL,ZHANG SW,et al.Incidence,mortality,and temporal patterns of oropharyngeal cancer in China:a population-based study[J].Cancer Commun(Lond),2018,38(1):75.
[12] DICKINSON A,SARASWAT M,SYRJANEN S,et al.Comparing serum protein levels can aid in differentiating HPV-negative and-positive oropharyngeal squamous cell carcinoma patients[J].PLoS One,2020,15(6):e233974.
[13] CHERA BS,KUMAR S,SHEN C,et al.Plasma circulating tumor HPV DNA for the surveillance of cancer recurrence in HPV-associated oropharyngeal cancer[J].J Clin Oncol,2020,38(10):1050-1058.
[14] KREIMER AR,FERREIRO-IGLESIAS A,NYGARD M,et al.Timing of HPV16-E6 antibody seroconversion before OPSCC:findings from the HPVC3 consortium[J].Ann Oncol,2019,30(8):1335-1343.
[15] MENA M,TABERNA M,TOUS S,et al.Double positivity for HPV-DNA/p16(ink4a)is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients[J].Oral Oncol,2018,78:137-144.
[16] BALACHANDRA S,KUSIN SB,LEE R,et al.Blood-based biomarkers of human papillomavirus-associated cancers:A systematic review and meta-analysis[J].Cancer,2021,127(6):850-864.
[17] WESTRICH JA,VERMEER DW,SILVA A,et al.CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8(+)T-cell responses by upregulating MHC-I expression[J].Oncogene,2019,38(46):7166-7180.
[18] ZHANG S,WANG B,MA F,et al.Characteristics of B lymphocyte infiltration in HPV(+)head and neck squamous cell carcinoma[J].Cancer Sci,2021,112(4):1402-1416.
[19] HLADIKOVA K,KOUCKY V,BOUCEK J,et al.Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8(+)T cells[J].J Immunother Cancer,2019,7(1):261.
[20] KOMDEUR FL,PRINS TM,VAN DE WALL S,et al.CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer[J].Oncoimmunology,2017,6(9):e1338230.
[21] SOLOMON B,YOUNG RJ,BRESSEL M,et al.Identification of an excellent prognosis subset of human papillomavirus-associated oropharyngeal cancer patients by quantification of intratumoral CD103+ immune cell abundance[J].Ann Oncol,2019,30(10):1638-1646.
[22] MIRGHANI H,AMEN F,MOREAU F,et al.Human papilloma virus testing in oropharyngeal squamous cell carcinoma:what the clinician should know[J].Oral Oncol,2014,50(1):1-9.
[23] PRIGGE ES,ARBYN M,VON KNEBEL DM,et al.Diagnostic accuracy of p16(INK4a)immunohistochemistry in oropharyngeal squamous cell carcinomas:A systematic review and meta-analysis[J].Int J Cancer,2017,140(5):1186-1198.
[24] GILLISON ML,TROTTI AM,HARRIS J,et al.Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer(NRG Oncology RTOG 1016):a randomised,multicentre,non-inferiority trial[J].LANCET,2019,393(10166):40-50.
[25] ANG KK,ZHANG Q,ROSENTHAL DI,et al.Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage Ⅲ to Ⅳ head and neck carcinoma:RTOG 0522[J].J Clin Oncol,2014,32(27):2940-2950.
[26] CHEN AM,FELIX C,WANG PC,et al.Reduced-dose radiotherapy for human papillomavirus-associated squamous-cell carcinoma of the oropharynx:a single-arm,phase 2 study[J].Lancet Oncol,2017,18(6):803-811.
[27] CRACCHIOLO JR,BAXI SS,MORRIS LG,et al.Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features:National Cancer Data Base[J].Cancer,2016,122(10):1523-1532.
[28] DE ALMEIDA JR,LI R,MAGNUSON JS,et al.Oncologic outcomes after transoral robotic surgery:a multi-institutional study[J].JAMA Otolaryngol Head Neck Surg,2015,141(12):1043-1051.
[29] CHIA SH,GROSS ND,RICHMON JD.Surgeon experience and complications with transoral robotic surgery(TORS)[J].Otolaryngol Head Neck Surg,2013,149(6):885-892.
[30] FAKHRY C,ZHANG Q,NGUYEN-TAN PF,et al.Development and validation of nomograms predictive of overall and progression-free survival in patients with oropharyngeal cancer[J].J Clin Oncol,2017,35(36):4057-4065.
[31] ZHAN KY,PURAM SV,LI MM,et al.National treatment trends in human papillomavirus-positive oropharyngeal squamous cell carcinoma[J].Cancer,2020,126(6):1295-1305.
[32] FUNG N,FARAJI F,KANG H,et al.The role of human papillomavirus on the prognosis and treatment of oropharyngeal carcinoma[J].Cancer Metastasis Rev,2017,36(3):449-461.
[33] SANCHEZ-CANTELI M,GRANDA-DIAZ R,DEL RN,et al.PD-L1 expression correlates with tumor-infiltrating lymphocytes and better prognosis in patients with HPV-negative head and neck squamous cell carcinomas[J].Cancer Immunol Immunother,2020,69(10):2089-2100.
[34] YOUNG RJ,BRESSEL M,PORCEDDU S,et al.Validation and characterisation of prognostically significant PD-L1(+)immune cells in HPV+ oropharyngeal squamous cell carcinoma[J].Oral Oncol,2020,101:104516.
[35] WELTERS M,MA W,SANTEGOETS S,et al.Intratumoral HPV16 specific T cells constitute a type Ⅰ-oriented tumor microenvironment to improve survival in HPV16-driven oropharyngeal cancer[J].Clin Cancer Res,2018,24(3):634-647.
[36] LEHTINEN M,DILLNER J.Clinical trials of human papillomavirus vaccines and beyond[J].Nat Rev Clin Oncol,2013,10(7):400-410.
[37] STANLEY M,PINTO LA,TRIMBLE C.Human papillomavirus vaccines-immune responses[J].Vaccine,2012,30(5):F83-F87.
[38] MARKOWITZ LE,NALEWAY AL,KLEIN NP,et al.Human papillomavirus vaccine effectiveness against HPV infection:evaluation of one,two,and three doses[J].J Infect Dis,2020,221(6):910-918.

Memo

Memo:
National Natural Science Foundation of China(No.31570989);国家自然科学基金面上项目(编号:31570989)
Last Update: 2021-12-31