|Table of Contents|

Identification of key biomarkers in gastric cancer based on integrated bioinformatics analysis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 03
Page:
476-480
Research Field:
Publishing date:

Info

Title:
Identification of key biomarkers in gastric cancer based on integrated bioinformatics analysis
Author(s):
LI Chao1; GENG Yanfang2; HONG Zhantong1
1.Department of Central Laboratory,Foshan Women and Children Hospital Affiliated to Southern Medical University,Guangdong Foshan 528000,China;2.Department of Science & Education Division,the Eastern Hospital of First Hospital Affiliated to Sun Yat-sen University,Guangdong Guangzhou 510080,China.
Keywords:
gastric cancer; bioinformatics; chip mining; key gene screening
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2022.03.020
Abstract:
Objective:To identify biomarkers of gastric cancer,we unearthed key genes through integrated bioinformatics.Methods:In this study,the datasets were downloaded from the database of GEO expression profiles for joint analysis.And differentially expressed genes(DEGs) were mined with R language,which also were enriched with functional annotations and pathways.The key genes were identified by String database and Cytoscape software.Then the genes were verified by Oncomine databases.Results:A total of 98 common DEGs were identified in this study,including 30 up-regulated and 68 down-regulated genes.Significant functional pathways of DEGs included extracellular matrix-receptor interactions,focal adhesions,retinol metabolism and gastric acid secretion pathways.Gene ontology(GO) enrichment analysis found that DEGs were involved in processes such as transmembrane receptors,transmembrane receptors,extracellular matrixand tissue homeostasis.10 possible key genes were excavated through protein-protein interaction(PPI) networks,and survival curve analysis revealed that SPP1 and MMP9 may be associated with patient prognosis of gastric cancer.Conclusion:The DEGs and 10 key genes identified in this study help us understand the molecular mechanisms of gastric cancer and provide new candidate biomarkers for the screening and treatment of gastric cancer.

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Memo

Memo:
广东省佛山市科学技术局医学类科技攻关计划项目（编号：2020001005606）
Last Update: 2021-12-31