[1]CHEN YP,CHAN TC,LE QT,et al.Nasopharyngeal carcinoma［J］.Lancet,2019,394(10192):64-80.
[2]BRAY F,FERLAY J,SOERIJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin,2018,68(6):394-424.
[3]WANG CQ,HE J.Ubiquitous distribution of Epstein-Barr virus and the highly uneven distribution of nasopharyngeal carcinoma［J］.Chin Med J(Engl),2016,129(20):2506-2507.
[4]RAZAK AR，SIU LL，LIU FF，et al．Nasopharyngeal carcinoma:the next challenges［J］．Eur J Cancer，2010，46(11):1967-1978．
[5]JENSEN LD.The circadian clock and hypoxia in tumor cell de-differentiation and metastasis［J］.Biochim Biophys Acta,2015,1850(8):1633-1641.
[6]WANG J,HOU WT,QIN XM,et al.Research progress of circadian rhythm［J］.China Journal of Chinese Materia Medica,2021,46(13):3240-3248.
[7]LIN YM，CHANG JH，YEH KT，et al． Disturbance of circadian gene expression in hepatocellular carcinoma［J］．Molecular Carcinogenesis，2008，47(12):925-933．
[8]STRAIF K,BAAN R,GROSSE Y，et al．Carcinogenicity of shift-work,painting,and fire-fighting［J］．Lancet Oncol，2007，8(12):1065-1066．
[9]DAVIS S,MIRICK DK,STEVENS RG.Night shift work，light at night，and risk of breast cancer［J］．J Natl Cancer Inst，2001，93(20):1557-1562．
[10]DONG Z,ZHANG G,QU M,et al．Targeting glioblastoma stem cells through disruption of the circadian clock［J］.Cancer Discov,2019,9(11):1556-1573.
[11]SHEN H,COOK K,GEE HE,et al.Hypoxia,metabolism,and the circadian clock:new links to overcome radiation resistance in high-grade gliomas［J］.J Exp Clin Cancer Res,2020,39(1):129.
[12]CHANG WH,LAI AG.Timing gone awry:distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies［J］.J Transl Med,2019,17(1):132.
[13]MORGAN MN,DVUCHBABNY S,MARTINEZ CA,et al.The cancer clock is(Not) ticking:Links between circadian rhythms and cancer［J］.Clocks Sleep,2019,1(4):435-458.
[14]BEGEMANN K,NEUMANN A,OSTER H.Regulation and function of extra-SCN circadian oscillators in the brain［J］.Acta Physiologica,2020,229(1):e13446.
[15]KELLEHEＲ FC,ＲAO A,MAGUIＲE A．Circadian molecular clocks and cancer［J］．Cancer Letters，2014，342(1):9-18．
[16]YE H,YANG K,TAN XM，et al．Daily rhythm variations of the clock gene PEＲ1 and cancer - related genes during various stages of carcinogenesis in a golden hamster model of buccal mucosa carcinoma［J］．Onco Targets Ther，2015，8:1419-1426．
[17]ZHAO N，YANG K，YANG G，et al．Aberrant expression of clock gene period1 and its correlations with the growth，proliferation and metastasis of buccal squamous cell carcinoma［J］．PLoS One，2013，8(2):e55894．
[18]LIU XY,XU XH.Hypoxic microenvironment and tumor treatment resistance［J］.Guangdong Medical Journal,2013,34(023):3667-3669.
[19]WU Y,TANG D,LIU N,et al.Reciprocal regulation between the circadian clock and hypoxia signaling at the genome level in mammals［J］.Cell Metab,2017,25(1):73-85.
[20]ELSHAZLEY M,SATO M,HASE T,et al.The circadian clock gene BMAL1 is a novel therapeutic targetfor malignant pleural mesothelioma［J］.International Journal of Cancer，2012，131(aop)：2820-2831.
[21]HE QY,JIN F,LI YY,et al.Prognostic significance of downregulated BMAL1 and upregulated Ki-67 proteins in nasopharyngeal carcinoma［J］.Chronobiology International,2018,35(3)：348-357.
[22]CHAN-HUN JUNG,EUN MI KIM,JONG KUK PARK.Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway［J］.Oncology Reports,2013,29(6):2109-2113.
[23]TIPHAINE M,PATRICK M,FREDERIC T,et al.Circadian clock characteristics are altered in human thyroid malignant nodules［J］.J Clin Endocrinol Metab,2013,98(11):4446-4456.
[24]DU SQ，JIANG HT，ZHONG JL，et al.Research progress of rhythm genes in colorectal cancer［J］．Hainan Med J，2019，30(19):2548-2551.
[25]MENG X,GAN JY,ZHOU JX,et al.Effect of clock gene BMAL1 on radiosensitivity of transplanted nasopharyngeal carcinoma［J］.Chinese Journal of Oncology,2020,047(001):12-17.
[26]SUYAMA K,SILAGI ES,CHOI H,et al.Circadian factors BMAL1 and RORalpha control HIF-1alpha transcriptional activity in nucleus pulposus cells：implications in maintenance of intervertebral disc health［J］.Oncotarget,2016,7(17):23056-23071.
[27]EGG M,KOBLITZ L,HIRAYAMA J,et al.Linking oxygen to time:the bidirectional interaction between the hypoxic signaling pathway and the circadian clock［J］.Chronobiol Int,2013,30(4):510-529.
[28]YANG P,REECE EA.Role of HIF-1α in maternal hyperglycemia-induced embryonic vasculopathy［J］.Am J Obstet Gynecol,2011,204(4):332.e1-7.
[29]SEMENZA GL.Targeting HIF-1 for cancer therapy［J］.Nat Rev Cancer,2003,3(10)：721-732.
[30]SEMENZA GL.Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics［J］.Oncogene,2010,29(5):625.
[31]GONG L,LI XM,LI ZH,et al.HIF-1α Expression and clinical significance of and GLUT-1 in nasopharyngeal carcinoma［J］.Chinese Journal of Cancer,2012,22(004):269-275.