|Table of Contents|

Clinical effect of lenalidomide combined with rituximab and dexamethasone regimen in the treatment of refractory recurrent mantle cell lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
1020-1023
Research Field:
Publishing date:

Info

Title:
Clinical effect of lenalidomide combined with rituximab and dexamethasone regimen in the treatment of refractory recurrent mantle cell lymphoma
Author(s):
LIU FengDU MingzhuGAO FeiDAI JinqianYANG JincaiSONG Yanping
Department of Hematology,Xi'an Central Hospital,Shaanxi Xi'an 710004,China.
Keywords:
lenalidomiderituximabdexamethasonemantle cell lymphomarefractory and recurrent
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2021.06.025
Abstract:
Objective:To evaluate the clinical efficacy and safety of lenalidomide combined with rituximab and dexamethasone in the treatment of refractory recurrent mantle cell lymphoma.Methods:25 patients with refractory recurrent mantle cell lymphoma treated with lenalidomide plus rituximab and dexamethasone regimen were retrospectively analysed.Lenalidomide was 15 mg/(m2·d),days 1~21,then was stopped for 7 days.Rituximab was 375 mg/m2 per week for 4 weeks,and dexamethasone 10 mg/d for 2 weeks,28 days for a course of treatment.All patients were followed up until March 2019.Results:After 3 courses of treatment,8 patients achieved complete remission (CR) (32.0%),6 patients with partial remission (PR) (24.0%),7 patients with stable disease (SD) (28.0%),and 4 patients with disease progression (PD) (16.0%).The total effective rate was 56.0%.The total effective rate was 64% after treatment.25 patients had a 1-year overall survival (OS) rate of 70%,and the 1-year disease-free survival (DFS) rate was 45%.No treatment-related deaths occurred in all patients.Adverse reactions were safe and controllable.Conclusion:Lenalidomide combined with rituximab and dexamethasone is safe and effective in the treatment of patients with refractory recurrent mantle cell lymphoma.The treatment-related side effects are well tolerated.This chemotherapy regimen can be used as a salvage treatment for refractory recurrent mantle cell lymphoma.

References:

[1]RICHA DAWAR,FRANCISCO HERNANDEZ-ILIZALITURRI.The emerging role of lenalidomidein themanagement of mantle cell lymphoma (MCL)[J].Best Pract Res Clin Haematol,2012,25(2):185-190.
[2]CAMPO E,RULE S.Mantle cell lymphoma:evolving management strategie[J].Blood,2015,125:48-55.
[3]CORTELAZZO S,PONZONI M,FERRERI AJ,et al.Mantle cell lymphoma [J].Crit Rev Oncol Hematoal,2012,82(1):78-101.
[4]刘耀,张曦.套细胞淋巴瘤的治疗现状及进展[J].临床荟萃,2014,29(10):1140-1146. LIU Y,ZHANG X.Treatment and advance in mantle cell lymphoma[J].Clinical Collection,2014,29(10):1140-1146.
[5]谢彦,朱军.套细胞淋巴瘤诊断与治疗中国专家共识(2016版)解读[J].临床血液学杂志,2017,30(9):683-686. XIE Y,ZHU J.The interpretation of the Chinese expert consensus to mantle cell lymphoma(2016 edition) [J].Journal of Clinical Hematology,2017,30(9):683-686.
[6]WILLIAMS ME,DREYLING M,WINTER J,et al.Management of mantle cell lymphoma:key challenges and next steps [J].Clin Lymphoma Myeloma Leuk,2010,10:336-346.
[7]DREYLING M,THIEBLEMONT C,GALLAMINI A,et al.ESMO consensus conferences:guidelines on malignant lymphoma.Part 2:marginal zone lymphoma,mantle cell lymphoma,peripheral T-cell lymphoma[J].Ann Oncol,2013,24:857-877.
[8]RUAN J,MARTIN P,SHAH B,et al.Lenalidomide plus rituximab as initial treatment for mantle-cell lymphoma[J].N Engl J Med,2015,373(19):1835-1844.
[9]LENZ G,DREYLING M,HOSTER E,et al.Immunochemotherapy with rituximab and cyclophosphamide,doxorubicin,vincristine,and prednisone significantly improves response and time to treatment fail[J].J Clin Oncol,2005,23(9):1984-1992.
[10]REDDY N,DEEB G,ROTH M,et al.Immunomodulatory drugs stimulate natural killer cell function,alter cytokine production by dendritic cells,and inhibit angiogenesis enhancing the antitumour activity of rituximab in vivo [J].Br J Haematol,2008,140(1):36-45.
[11]LUO J,GAGNE JJ,LANDON J,et al.Comparative effectiveness and safety of thalidomide and lenalidomide in patients with multiple myeloma in the United States of America:A population-based cohort study[J].Eur J Cancer,2017,70:22-33.
[12]LISTER TA,CROWTHER D,SUTCLIFFE SB,et al.Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin' s disease:Cotswolds meeting[J].J Clin Oncol,1989,7(11):1630-1636.
[13]CHESON BD,PFISTNER B,JUWEID ME,et al.Revised response criteria for malignant lymphoma[J].J Clin Oncol,2007,25(5):579-586.
[14]冯艺,周宇红.利妥昔单抗联合CHOP化疗方案治疗B细胞非霍奇金淋巴瘤感染病例观察[J].中国临床医学,2010,17(6):889-891. FENG Y,ZHOU YH.The observation study of infection cases occurred during rituximab in combination with CHOP chemotherapy for B cell non-Hodgkin's lymphoma[J].Chinese Journal of Clinical Medicine,2010,17 (6):889-891.
[15]陆卫华.利妥昔单抗联合CHOP治疗弥漫型大B细胞淋巴瘤效果观察[J].临床合理用药,2019,12(2A):24-25. LU WH.Effect observation of rituximab combined with CHOP in treatment of diffuse large B-cell lymphoma [J].Clinically Reasonable Medication,2019,12(2A):24-25.
[16] KAUFMANN H,RADERER M,W HRER S,et al.Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma[J].Blood,2004,104(8):2269-2271.
[17]SKARBNIK AP,GOY AH.Lenalidomide for mantle cell lymphoma[J].Expert Rev Hematol,2015,8(3):257-264.
[18]RAMSAY AG,CLEAR AJ,KELLY G,et al.Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide:implications for the tumor microenvironment and immunotherapy[J].Blood,2009,114(21):4713-4720.
[19]WITZIG TE,WIERNIK PH,MOORE T,et al.Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin' s lymphoma[J].J Clin Oncol,2009,27(32):5404-5409.
[20]ZAJA F,DE LUCA S,VITOLO U,et al.Salvage treatment with lenalidomide and dexamethasone in relapsed/refractory mantle cell lymphoma:clinical results and effects on microenvironment and neo-angiogenic biomarkers[J].Haematologica,2012,97:416-422.
[21]王晓平,李晖,吉晓春,等.雷利度胺联合利妥昔单抗治疗复发性滤泡性淋巴瘤的疗效[J].广东医学,2017,38(21):3350-3356. WANG XP,LI H,JI XC,et al.Efficacy analysis of lenalidomide combined with rituximab in recurrent follicular lymphoma [J].Guangdong Medicine,2017,38(21):3350-3356.

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