|Table of Contents|

Relationship between systemic immune-inflammatory index(SII) and clinical pathological features and prognosis in patients with gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
441-445
Research Field:
Publishing date:

Info

Title:
Relationship between systemic immune-inflammatory index(SII) and clinical pathological features and prognosis in patients with gastric cancer
Author(s):
ZHANG Yu; WANG Yimin; XUE Yingwei
Cancer Hospital，Harbin Medical University，Heilongjiang Harbin 150081，China．
Keywords:
gastric cancer; systemic immune-inflammation index; radical surgery; prognosis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2021.03.017
Abstract:
Objective：To investigate the relationship between preoperative systemic immune-inflammation index(SII) and clinical pathological features and prognosis in patients with gastric cancer.Methods：The clinical and pathological data of 823 patients undergoing radical surgery for gastrointestinal surgery at the Affiliated Tumor Hospital of Harbin University from January 2010 to December 2013 were retrospectively analyzed.SII was calculated based on preoperative test results(SII=platelets×neutrophils/lymphocytes)，using the ROC curve to capture the optimal cut-off value.The SII was divided into two groups.The relationship between SII and clinical pathological factors was analyzed.The survival curve was drawn by Kaplan-Meier method.The single factor analysis was performed by Log-rank method，and the multivariate analysis was performed by COX regression risk model.Results：The optimal SII cut-off value was 427.3.There were 459 patients in the SII≤427.3 group and 364 patients in the SII>427.3 group.SII was associated with age，infiltration，number of lymph node metastases，TNM stage，albumin，pre-albumin，A/G，and CEA(both P<0.05).As of March 2018，there were 514 survivors and 309 deaths，and the overall survival(OS) of patients with SII ≤427.3 was significantly better than that of SII>427.3 patients.The difference was statistically significant(P=0.000)，single-factor analysis results showed that age，tumor location，differentiation,tumor infiltration，number of lymph node metastasis，TNM stage，albumin count，pre-albumin count，A/G，CEA，CA-199 and SII were associated with prognosis of radically operated gastric cancer patients(P<0.05).Multivariate analysis showed that age(HR=1.487，95%CI=1.162~1.902，P=0.020)，tumor location(HR=0.696，95%CI=0.597~0.811，P=0.000),degree of tumor infiltration(HR=2.241，95%CI=1.184~4.244，P=0.013)，number of lymph node metastasis(HR=1.337，95%CI=1.121~1.595，P=0.001)，TNM staging(HR=1.289，95%CI=1.067~1.558，P=0.008)，pre-albumin(HR=0.720，95%CI=0.560~0.926，P=0.010)，CA-199(HR=1.513，95%CI=1.204~1.901，P=0.000) and SII(HR=1.577，95%CI=1.253~1.984，P=0.000)，were independent risk factors for the prognosis of patients with radical gastric cancer.Conclusion：SII is a reliable prognostic indicator for gastric cancer patients undergoing radical surgery，and high preoperative SII indicates poor prognosis.

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Memo

Memo:
哈尔滨市科技局应用技术研究与开发项目(编号：2017RAXXJ054)；哈尔滨医科大学附属肿瘤医院优秀学科(NnlO计划)培育项目(编号：Nnl0PY2017-03)
Last Update: 2020-12-31