|Table of Contents|

Effects of transurethral resection of bladder tumor combined with adjuvant arterial chemotherapy on postoperative urinary continence,sexuality and tumor control effects in patients with bladder cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
437-441
Research Field:
Publishing date:

Info

Title:
Effects of transurethral resection of bladder tumor combined with adjuvant arterial chemotherapy on postoperative urinary continence,sexuality and tumor control effects in patients with bladder cancer
Author(s):
ZHANG Gang
Department of Urinary Surgery,Zibo First Hospital,Shandong Zibo 255200,China.
Keywords:
TURBTarterial chemotherapybladder cancerurinary continencesexualitytumor control effects
PACS:
R737.14
DOI:
10.3969/j.issn.1672-4992.2021.03.016
Abstract:
Objective:To explore the effects of transurethral resection of bladder tumor(TURBT) combined with adjuvant arterial chemotherapy on postoperative urinary continence,sexuality and tumor control effects in patients with bladder cancer.Methods:92 cases of patients with bladder cancer treated with TURBT in our hospital from May 2013 to May 2015 were selected for the study and randomly divided into observation group(n=46) and control group(n=46).Control group was given TURBT+postoperative infusion chemotherapy,and observation group was given preoperative arterial chemotherapy+TURBT surgery+postoperative infusion chemotherapy.The perioperative situation and postoperative urinary continence rate at different times,international index of erectile function questionnaire(IIEF-5) score,recurrence rate,overall survival rate(OS) and general quality of life questionnaire(GQOLI-74) score were compared between the two groups.Results:The intraoperative blood loss,operative time,catheter indwelling time and hospital stay in observation group were significantly less than those in control group(P<0.05).There was no significant difference in the IIEF-5 score at 3 months after operation between the two groups(P>0.05),and the IIEF-5 score and urinary continence rate at other time points after operation were significantly higher in observation group than those in control group(P<0.05).There was no significant difference in the mortality rate between the two groups at 6,12 and 24 months after operation(P>0.05).The scores of physical function,social function,material life and mental function in observation group at 6,12 and 24 months after operation were significantly higher than those in control group(P<0.05).Conclusion:TURBT combined with adjuvant arterial chemotherapy can effectively control the bladder cancer,and improve physical function,social function and psychological function and other related quality of life.

References:

[1]SOO KB,SIK TB,HYEON KJ,et al.Rate and association of lower urinary tract infection with recurrence after transurethral resection of bladder tumor[J].Investigative and Clinical Urology,2018,59(1):10-17.
[2]KANG GR,SOHN DW,CHUNG DJ.A case of extravesical metastases occurring after transurethral resection of non-invasive bladder cancer[J].Journal of the Korean Society of Radiology,2018,78(2):141-144.
[3]LEE J,JEH SU,KOH DH,et al.Probe-based confocal laser endomicroscopy during transurethral resection of bladder tumors improves the diagnostic accuracy and therapeutic efficacy[J].Ann Surg Oncol,2019,26(4):1157-1165.
[4]符伟军.膀胱癌患者诊疗指南[M].北京:人民军医出版社,2014:22-24. FU WJ.The guidelines of diagnosis and treatment for patients with bladder cancer[M].Beijing:People' s Military Medical Press,2014:22-24.
[5]KATHERINE A,ALVARO L.Stress urinary incontinence management in the patient with overactive bladder[J].Current Bladder Dysfunction Reports,2018,13(3):111-117.
[6]LIAO L,CHUANG YC,LIU SP,et al.Effect of lower urinary tract symptoms on the quality of life and sexual function of males in China,Taiwan,and South Korea:Subgroup analysis of a cross-sectional,population-based study[J].Luts Lower Urinary Tract Symptoms,2019,11(2):78-84.
[7]戴涟生,叶俊星,杨晓斐,等.三联药物注射辅助治疗Ⅱ-Ⅲ级老年KOA临床研究[J].中国医院药学杂志,2018,38(3):295-297,261. DAI LS,YE JX,YANG XF,et al.Clinical study of three drug injection therapy combined with arthroscopic debridement in the treatment of elderly patients with grade Ⅱ-Ⅲ knee osteoarthritis[J].Chinese Journal of Hospital Pharmacy,2018,38(3):295-297,261.
[8]赵继明,祝筠.膀胱癌患者手术前后生命质量变化及影响因素分析[J].中华肿瘤防治杂志,2017,24(15):1030-1034. ZHAO JM,ZHU Y.Analysis of life quality before and after operation and its influential factors in patients with bladder cancer[J].Chinese Journal of Cancer Prevention and Treatment,2017,24(15):1030-1034.
[9]ZAINFELD D,DANESHMAND S.Transurethral resection of bladder tumors:improving quality through new techniques and technologies[J].Current Urology Reports,2017,18(5):34.
[10]KIM HS,JEONG CW,KWAK C,et al.Adjuvant chemotherapy for muscle-invasive bladder cancer:a systematic review and network meta-analysis of randomized clinical trials[J].Oncotarget,2017,8(46):81204-81214.
[11]PALOU J,PISANO F,SYLVESTER R,et al.Recurrence,progression and cancer-specific mortality according to stage at re-TUR in T1G3 bladder cancer patients treated with BCG:not as bad as previously thought[J].World Journal of Urology,2018,16(3):1-7.
[12]VALE CL.Adjuvant chemotherapy for invasive bladder cancer(individual patient data)[J].Der Urologe,2017,56(2):237-240.
[13]王志,申凯,廖有刚.经腹膜外改良逆行膀胱全切术+原位回肠新膀胱术治疗男性浸润性膀胱癌临床观察[J].医学临床研究,2017,34(9):1711-1714. WANG Z,SHEN K,LIAO YG.Clinical analysis of modified radical cystectomy combined with orthotopic ileal neobladder for invasive bladder cancer in male patients[J].Journal of Clinical Research,2017,34(9):1711-1714.
[14]GAN Y,HE L,YAO K,et al.Knockdown of HMGN5 increases the chemosensitivity of human urothelial bladder cancer cells to cisplatin by targeting PI3K/Akt signaling[J].Oncology Letters,2017,14(6):6463-6470.
[15]ZHUO Y,CHEN Q,CHEN B,et al.Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest[J].Int J Clin Pharmacol Ther,2017,55(1):32-40.
[16]YANSHI X,LIN Y,JUNZUN L,et al.Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway[J].OncoTargets and Therapy,2018,11(1):4413-4429.
[17]瓦斯里江?瓦哈甫,刘赛,王梦童,等.膀胱癌根治术前单次动脉灌注化疗的长期疗效评估[J].首都医科大学学报,2018,39(03):117-121. WASILIJIANG?WHF,LIU S,WANG MT,et al.Long-term efficacy of one-shot intra-arterial chemotherapy before radical cystectomy[J].Journal of Capital Medical University,2018,39(03):117-121.

Memo

Memo:
-
Last Update: 2020-12-31