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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2021 03

Page:

427-431

Research Field:

Publishing date:

Info

Title:

Analysis of clinicopathological features of double primary breast cancer and lung cancer

Author(s):

ZHANG Wenxiang¹; JI Ying²; ZHAI Jie¹; KONG Xiangyi¹; AI Bolun¹; FANG Yi¹; WANG Jing¹

1.Department of Breast Surgical Oncology；2.Department of Thoracic Surgery，National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100021，China.

Keywords:

breast cancer; lung cancer; double primary cancer; pathological features; prognosis

PACS:

R737.9；R734.2

DOI:

10.3969/j.issn.1672-4992.2021.03.014

Abstract:

Objective：To analysis the clinicopathological features of double primary breast cancer and lung cancer and explore the safety of concomitant surgical treatment.Methods：A total of 94 patients with breast cancer and lung cancer in Cancer Hospital of Chinese Academy of Medical Sciences from January 1999 to December 2017 were retrospectively collected.71 patients were finally included in this study.The clinicopathological characteristics of breast cancer and primary lung cancer were analyzed.Results：Among the 71 double primary cases，63 patients firstly appear breast cancer，while 8 patients show up lung cancer first.There was no significant association in breast tumor size，the status of lymph node metastases，clinical-stage，pathological type，ER expression，Ki-67 index，HER-2 expression，surgical method，and history of radiotherapy and chemotherapy(P>0.05) between the two groups.But the progression-free survival of breast cancer patients with second primary lung cancer(BC2LuC) was better than lung cancer patients with second primary breast cancer(LuC2BC)(P<0.05).Among the 28 cases of synchronous double primary cancer，6 patients(21.4%) underwent surgery for breast cancer and lung cancer at the same time.There were no perioperative complications and the condition was stable after operation.For breast cancer patients with metachronous second primary malignancy of lung cancer，the median interval was 57.3 months and the average observation time for pulmonary nodules was 10 months.82.9% lung cancer are below stage I and 93% of the pathological types were adenocarcinoma.The foundation of lung nodules was related to breast cancer postoperative review and follow-up.Conclusion：Breast cancer with second primary lung cancer(BC2LuC) has a better prognosis.Concomitant surgery for synchronous breast and lung cancer was feasible and safe.In metachronous cases，lung cancers tended to be detected within 5 years after surgery for breast cancer.Careful follow-up for postoperative breast cancer may contribute to the detection of early-stage lung cancer.

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Last Update: 2020-12-31