|Table of Contents|

The relationship between immune infiltrating cells and clinicopathological characteristics in differentiated thyroid carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
397-402
Research Field:
Publishing date:

Info

Title:
The relationship between immune infiltrating cells and clinicopathological characteristics in differentiated thyroid carcinoma
Author(s):
XU PeiGUAN Haixia
Department of Endocrinology and Metabolism,the Endocrine Institute and the Liaoning Provincial Key Laboratory of Endocrine Diseases,the First Hospital of China Medical University,Liaoning Shenyang 110001,China.
Keywords:
DTCimmune microenviromentimmune infiltrating cellsinfiltratingclinicopathological characteristicstumor staging
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2021.03.007
Abstract:
Objective:To explore immune infiltrating cells distribution in differentiated thyroid carcinoma (DTC) and to study the relationship between cells and clinical features.Methods:Transcripts and cilinical data were downloaded from TCGA calculate 22 types of immune cells infiltrating in thyroid by using CIBOSORT,and different immune infiltrating cells were compared between DTC and normal thyroid,and association was andysed between cells and different tumor staging.Results:M0 macrophages,M2 macrophages,resting dendritic cells and resting mast cells in DTC were significantly higher than those in normal thyroid.Furthermore,CD8+T cells and plasma cells in AJCC stage Ⅲ/Ⅳ patients were lower than in AJCC stage Ⅰ/Ⅱ patients (P<0.05),while the abundance of monocytes,activated mast cells and resting dendritic cells in DTC increased with AJCC stage (P<0.05).Conclusion:The predominant types of immune infiltrating cells in thyroid are related to tumor progression,indicating that immune cell existing in microenvironment may prompt tumor progression,and certain immune cell types may assess tumor risks.

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辽宁省重点研发计划指导计划(编号:2017225008);辽宁省“百千万人才工程”培养经费资助项目—沈阳市中青年科技创新人才支持计划(编号:RC170058)
Last Update: 2020-12-31