|Table of Contents|

Analysis of correlation between VacA gene and VEGF expression in oral squamous cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 03
Page:
402-406
Research Field:
Publishing date:

Info

Title:
Analysis of correlation between VacA gene and VEGF expression in oral squamous cell carcinoma
Author(s):
DING Yunbo; YAO Xiaowu; CHEN Shisheng; LU Zizheng; LIN Minxiao; GUI Xinwei
Department of Stomatology，the Second Affiliated Hospital，Medical College of Shantou University，Guangdong Shantou 515041，China.
Keywords:
oral squamous cells carcinoma; Helicobacter pylori; VacA gene; VEGF
PACS:
R739.85
DOI:
10.3969/j.issn.1672-4992.2021.03.008
Abstract:
Objective：To detect the presence of Helicobacter pylori virulence factor VacA gene and its correlation with VEGF expression in oral squamous cell carcinoma (OSCC) tissues，and explore the relationship between Helicobacter pylori and oral squamous cell carcinoma.Methods：The polymerase chain reaction (PCR) was used to detect the positive rate of VacA gene in 40 cases of oral squamous cell carcinoma tissues and 23 normal mucosal tissues，and the immunohistochemical staining was used to detect the expression of VEGF.The difference in VEGF expression between VacA gene positive and negative groups in oral cancer tissues was compared.Results：The positive rate of VacA gene was 25% in OSCC and 0 in normal oral mucosa，and the difference was statistically significant (P=0.024).The strong positive rate of VEGF in OSCC of VacA positive group was higher than that of VacA negative group (P=0.018)，and the average optical density of VEGF in VacA positive group was higher than that of VacA negative group (P=0.023).The difference was statistically significant.Conclusion：There is VacA gene in OSCC，and it may be related to VEGF expression.Whether Helicobacter pylori affects the occurrence and development of OSCC through the regulation of VEGF expression by VacA virulence factors should be further studied.

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Memo

Memo:
广东省科技计划（编号：2013B021800260）;汕头市医疗卫生科技计划（编号：汕府科［2018］11号）
Last Update: 2020-12-31