|Table of Contents|

Expression and significance of FXR and CDX2 in gastric mucosal intestinal metaplasia and gastric carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
967-972
Research Field:
Publishing date:

Info

Title:
Expression and significance of FXR and CDX2 in gastric mucosal intestinal metaplasia and gastric carcinoma
Author(s):
Shi Miao1; Sun Nina2; Liu Caifang2; Ni Zhen3; 4; Han Chuan3; 5; Zhang Jian3; Yuan Ting3; 6; Shi Yongquan3
1.Department of Gastroenterology,the Second Affiliated Hospital of Xi'an Medical University,Shaanxi Xi'an 710038,China;2.The First Affiliated Hospital of Xi'an Medical University,Shaanxi Xi'an 710000,China;3.State Key Laboratory of Cancer Biology & Xijin
Keywords:
bile acid; farnesoid X receptor(FXR); caudal type homeobox 2(CDX2); intestinal metaplasia; gastric carcinoma
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2020.06.020
Abstract:
Objective:To investigate the expression and significance of farnesoid X receptor (FXR) and caudal type homeobox 2(CDX2) in the gastric mucosal intestinal metaplasia (IM) and gastric carcinoma.Methods:Immunohistochemical staining was used to detect the expression of FXR and CDX2 in 30 cases of chronic gastritis,50 cases of IM and 60 cases of gastric cancer.The chi-square test was used to compare the expression differences of FXR and CDX2 in each group,and the relationship between the expression of FXR and CDX2 and the clinicopathological parameters of intestinal metaplasia and gastric cancer patients was analyzed.Spearman rank correlation test was used to analyze the correlation between the FXR and CDX2 expression.Results:The high expression rates of FXR in IM and gastric cancer tissues were 58.0% and 38.3%,respectively,which were significantly higher than those in chronic gastritis (13.3%) (P<0.05).Compared with IM tissues,FXR expression was significantly decreased in gastric cancer tissues (P=0.040).High expression of FXR was associated with IM degree (moderate to severe of degree)(P=0.025) of patients with IM.High expression of FXR was associated with differentiation status (moderate or well of differentiation) (P=0.003) of patients with gastric cancer.The high expression rates of CDX2 in IM and gastric cancer tissues were 46.0% and 26.7%,respectively,which were significantly higher than those in chronic gastritis (6.7%) (P<0.05).Compared with IM tissues,CDX2 expression was significantly decreased in gastric cancer tissues (P=0.035).High expression of CDX2 was associated with IM degree (moderate to severe of degree) (P=0.004) of patients with IM.High expression of CDX2 was associated with differentiation status (moderate or well of differentiation) (P＜0.001) of patients with gastric cancer.There was a significant positive correlation between FXR and CDX2 expression in chronic gastritis,IM and gastric cancer tissues (P<0.001).Conclusion:FXR and CDX2 are up-regulated in IM and gastric cancer tissues and have a significant positive correlation.They may be involved in the occurrence and development of IM and gastric cancer.

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Memo

Memo:
National Natural Science Foundation of China（No.81873554）;国家自然科学基金项目(编号：81873554)；陕西省创新能力支撑计划项目(编号：2018TD-003)
Last Update: 2020-01-21