|Table of Contents|

Expression of miR-155 in MALT lymphoma tissues and its relationship with prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
806-809
Research Field:
Publishing date:

Info

Title:
Expression of miR-155 in MALT lymphoma tissues and its relationship with prognosis
Author(s):
Li Li1; Yang Yifei2; Yang Junchao1; Li Weimin1; Mao Dan1; Shi Xiaoxue1
1.Department of Hematology，Affiliated Hospital of Hebei University of Engineering，Hebei Handan 056000，China；2.Department of Discipline Construction and Graduate Education，Affiliated Hospital(School of Clinical Medicine)，Hebei University of Engineering，Hebei Handan 056000，China.
Keywords:
miR-155; MALT lymphoma; prognosis
PACS:
R733.4
DOI:
10.3969/j.issn.1672-4992.2020.05.026
Abstract:
Objective：To investigate the expression of miR-155 in MALT lymphoma and its relationship with prognosis.Methods：From 2007.03 to 2014.03,a total of 36 patients with MALT lymphoma who were first diagnosed in Department of Hematology of the Affiliated Hospital of Hebei University of Engineering tissues and paraneoplastic tissue (from tumor >2 cm) were collected.Using qPCR methods to detect the expression of miR-155 in tumor tissues and paraneoplastic tissues of patients with MALT lymphoma，then 36 patients were given CHOP regimen treatment for 8 cycles.According to the evaluation criteria of solid tumor efficacy，the patients were divided into active group and inactive group.Serum levels of miR-155 in two groups of patients were compared，and patients were followed-up by clinic or by phone.According to the threshold of the average value of miR-155 expression level，the patients were divided into miR-155 high expression group （23 patients）and miR-155 low expression group （13 patients）.The three-year survival rate of the two groups of patients was compared.Results：The expression levels of miR-155 in tumor tissues and paraneoplastic tissues respectively were 6.63±0.70 and 1.29±0.05，and the differences was statistically significant（P<0.05）.After 8 cycles of CHOP treatment，the serum levels of miR-155 in the effective and ineffective groups respectively were 2.21±0.14 and 7.01±0.54.The follow-up showed that after treatment the three-year survival rates of patients with miR-155 high expression group and miR-155 low expression group respectively were 56.5% and 76.9%，and the differences was statistically significant（P<0.05）.Conclusion：The expression level of miR-155 may be related to the development and prognosis of MALT lymphoma.

References:

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Memo

Memo:
河北省重点研发计划健康医疗与生物医药专项项目（编号：18277782D）；邯郸市科学技术研究与发展计划项目（编号：1723208068-2）
Last Update: 1900-01-01