|Table of Contents|

The clinical efficacy of bevacizumab combined with mFOLFOX6 in the treatment of metastatic colorectal cancer and the difference between left and right colon cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
779-783
Research Field:
Publishing date:

Info

Title:
The clinical efficacy of bevacizumab combined with mFOLFOX6 in the treatment of metastatic colorectal cancer and the difference between left and right colon cancer
Author(s):
Deng WenjingYu GengshengLiu AiFang Lilan
Department of Medical Oncology,Jiangmen Central Hospital,Affiliated Jiangmen Hospital of Sun Yat-sen University,Guangdong Jiangmen 529030,China.
Keywords:
bevacizumabcolorectal cancer/advanced metastasisleft/right colon cancer
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2020.05.019
Abstract:
Objective:To observe the efficacy and toxicity of bevacizumab combined with mFOLFOX6 in the treatment of advanced metastatic colorectal cancer,and to explore the difference in the efficacy of left and right colon cancer.Methods:72 patients with advanced metastatic colorectal cancer,33 cases in bevacizumab + mFOLFOX6 group and 39 cases in mFOLFOX6 group,were selected from January 2017 to August 2018 in the oncology department of Jiangmen Central Hospital.The therapeutic effects,median PFS and toxicity of the two groups were analyzed,and the effects of different treatment schemes on the effect of left and right colon cancer were analyzed.Results:The objective response rate (ORR) was 45.5% and the disease control rate (DCR) was 84.8% in bevacizumab+mFOLFOX6 group.The ORR was 38.5% and the DCR was 79.5% in mFOLFOX6 group.Kaplan-Meier analysis showed that the median PFS of mFOLFOX6 group and bevacizumab+mFOLFOX6 group were 6.2 months and 7.7 months,respectively(P=0.06).COX multivariate analysis showed that bevacizumab+mFOLFOX6 group and mFOLFOX6 group had significant effect on PFS (P= 0.024),while the number of treatment lines had no significant effect on PFS (P=0.059).Kaplan-Meier analysis showed that PFS of right and left colon cancer was 6.9 months and 8.1 months in bevacizumab + mFOLFOX6 group (P=0.538),and PFS of right and left colon cancer was 6.37 months and 6.2 months in mFOLFOX6 group (P=0.209).The main side effects of the two groups were gastrointestinal reaction,bone marrow suppression and neurotoxicity.The main side effects associated with bevacizumab were hypertension,proteinuria and thrombosis.Except for one case of hypertension with grade III,the others were grade I-II.Conclusion:Bevacizumab+mFOLFOX6 is effective and tolerable in the treatment of advanced metastatic colorectal cancer.It has a tendency to benefit PFS of left colon cancer.

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