|Table of Contents|

Effect of myeloid suppressor cell changes on childhood acute B lymphocytic leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 04
Page:
617-622
Research Field:
Publishing date:

Info

Title:
Effect of myeloid suppressor cell changes on childhood acute B lymphocytic leukemia
Author(s):
Han Xue1; Zhang Yanfang1; Song Guihua2
1.Department of Pediatrics,Kaifeng Children's Hospital,Henan Kaifeng 475000,China；2.Department of Pediatrics,First Affiliated Hospital of Henan College of Traditional Chinese Medicine,Henan Zhengzhou 450046,China.
Keywords:
B-ALL; MDSC; children
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2020.04.022
Abstract:
Objective：To investigate the effect of changes in MDSC on children's B-ALL.Methods:Peripheral blood samples were collected from children with B-ALL before and after induction remission and normal children.The number of MDSC（CD11b+CD33+) and the relative proportion of its two subgroups，including M-MDSC（CD14+CD11b+CD33+) and G-MDSC（CD15+CD11b+CD33+) were detected.The expression of Arg I and ROS was also detected and compared according to risk stratification.Results:Before induction remission treatment,the proportion of peripheral blood MDSC（CD11b+CD33+) in children with B-ALL was significantly higher than that in normal children（P＜0.01),which was significantly lower after induction remission treatment（P＜0.01),but still significantly higher than that in normal children（P＜0.01).Before induction remission treatment,G-MDSC（CD15+CD11b+CD33+) was the main subgroup of peripheral blood MDSC cells,and after induction remission treatment,M-MDSC（CD14+CD11b+CD33+) was the main subgroup.Before induction remission treatment,the expression levels of Arg I and ROS in peripheral blood of children with B-ALL were significantly higher than those after induction remission treatment（P＜0.01),and after induction remission treatment,they were still significantly higher than those of normal children（P＜0.01).The number of MDSC and the expression levels of Arg I and ROS were positively correlated with the risk stratification of B-ALL（P＜0.01).Conclusion:G-MDSC subsets of MDSC and functional substance ROS play an important role in the pathogenesis of B-ALL in children.

References:

[1] Elisabeth MP,Judith MB,Alex QH,et al.Copy number alterations in B-cell development genes,drug resistance,and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia［J］.Sci Rep,2019,9(1):4634.
[2] Jaqueline C,Gabriela M,Mirella B,et al.MiRNA dysregulation in childhood hematological cancer［J］.Int J Mol Sci,2018,19(9):2688.
[3] Greaves M.A causal mechanism for childhood acute lymphoblastic leukaemia［J］.Nature Reviews Cancer,2018,18(8):471-484.
[4] Hunger SP,Mullighan CG.Acute lymphoblastic leukemia in children［J］.N Engl J Med,2015,373(16):1541-1552.
[5] Katherine HP,Daniel WB,Suzanne OR.Myeloid-derived suppressor cells:Critical cells driving immune suppression in the tumor microenvironment［J］.Adv Cancer Res,2015,128(1):95-139.
[6] Vinit K,Sima P,Evgenii T,et al.The nature of myeloid-derived suppressor cells in the tumor microenvironment［J］.Trends Immunol,2016,37(3):208-220.
[7] Hematology Group,Society of Pediatrics,Chinese Medical Association.Recommendations for the diagnosis and treatment of childhood acute myeloid leukemia ［J］.Chinese Journal of Pediatrics,2006,44（11):877-878.［中华医学会儿科学分会血液学组.儿童急性髓细胞白血病诊疗建议［J］.中华儿科杂志,2006,44(11):877-878.］
[8] LI Yunhui,SUN Yong,LV Meifeng.Detection and clinical significance of plasma MDSCs in patients with ulcerative colitis ［J］.Guangxi Medical College,2014,36(7):930-932.［李运辉,孙勇,吕美锋.溃疡性结肠炎患者血浆MDSCs的检测及临床意义［J］.广西医学,2014,36(7):930-932.］
[9] Laura J,Iraklis C,André J,et al.6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice［J］.Cancer Immunol Immunother,2015,64(8):1033-1046.
[10] Douglas M,Dmitry I.Myeloid-derived suppressor cells in the tumor microenvironment:Expect the unexpected［J］.J Clin Invest,2015,125(9):3356-3364.
[11] Kumar S,Wilkes D,Samuel N,et al.ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer［J］.The Journal of Clinical Investigation,2018,128(11):5095-5109.
[12] Srivastava MK,Sinha P,Clements VK,et al.Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine［J］.Cancer Res,2010,70(1):68-77.
[13] Jie M,Huaxi X,Shengjun W.Immunosuppressive role of myeloid-derived suppressor cells and therapeutic targeting in lung cancer［J］.J Immunol Res,2018,62(9):631-649.
[14] Tatiana A,Todd J,Evgeniy E,et al.CD38-expressing myeloid-derived suppressor cells promote tumor growth in a murine model of esophageal cancer［J］.Cancer Res,2015,75(19):4074-4085.
[15] Veronica H,Viviana V,Viktor F,et al.Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma［J］.J Clin Invest,2018,128(12):5505-5516.
[16] Cesarina G,Daniele T,Nunziatina L,et al.Granulocyte-like myeloid derived suppressor cells（G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells（MSC)［J］.Oncotarget,2016,7(52):85764-85775.
[17] Gorgun GT,Whitehill G,Anderson JL,et al.Tumor promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans［J］.Blood,2013,121(15):2975-2987.
[18] XU Lili,LI Lijuan,ZHOU Wen,et al.Relevant research and application prospects of myelogenous suppressor cells in cancer therapy ［J］.Clinical Meta-analysis,2017,32(6):545-548.［许丽丽,李莉娟,周文,等.髓源性抑制细胞在肿瘤治疗中的相关研究及应用前景［J］.临床荟萃,2017,32(6):545-548.］
[19] La Face D,Talmadge J.Meeting report:Regulatory myeloid cells［J］.Int Immunopharmacol,2011,11(7):780-782.
[20] Nagaraj S,Schrum AG,Dmitry I,et al.Mechanism of T-cell tolerance induced by myeloid-derived suppressor cells［J］.J Immunol,2010,184(6):3106-3116.

Memo

Memo:
National Natural Science Foundation of China（No.81473728）;国家自然科学基金(编号：81473728)
Last Update: 2019-12-26