|Table of Contents|

The correlation of gene polymorphism of MDM2 T309G and prostate cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 04
Page:
614-616
Research Field:
Publishing date:

Info

Title:
The correlation of gene polymorphism of MDM2 T309G and prostate cancer
Author(s):
Mu Yudong1; Hao Nina1; Yuan Rong1; Zhang Tao2; He Lin1
1.Shaanxi Provincial Cancer Hospital，Shaanxi Xi'an 710061,China；2.Xi'an Central Hospital，Shaanxi Xi'an 710003,China.
Keywords:
MDM2; single nucleotide polymorphism; prostate cancer
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2020.04.021
Abstract:
Objective：To study the correlation of the single nucleotide polymorphism of MDM2 T309G and prostate cancer．Methods：The DNA was extracted by Phenol chloride.MDM2 T309G was examined by ploymerase chain reaction and restriction fragment length polymorphism in 100 cases of prostate cancer patients and 100 healthy people.Results：The frequency of G and T allele in the case group was 52.5% and 47.5%, in the control group was 40.5% and 59.5%. The distribution of MDM2 T309G genotype had significant differences in the two groups.The distribution of TT genotype in the case group was significantly lower in the control group（P＜0.05）.Conclusion：The distribution of MDM2 T309G genotype had significant differences in the two groups.G allele was associated with significantly increased risk for prostate cancer.

References:

[1]Siegel R，Naishadham D，Jemal A.Cancer statistics,2013［J］.Canc J Clinic，2013,63(1):11-30．
[2]ZHU G,ZHNAG K.Chinese prostate cancer screening:Current situation and challenges［J］.Journal of Shandong University,2019,57(1):11-15.［朱刚，张凯.中国前列腺癌筛查的现状和挑战［J］.山东大学学报，2019,57(1):11-15.］
[3] Meral Y,Ayca T,Gonca D,et al.Significant association of the MDM2 T309G polymorphism with breast cancer risk in a turkish population［J］.APJCP,2018,19(4):1059-1062.
[4] Ayca T,Mustafa A,Gulcin C,et al.Investigation of the association between the MDM2 T309G polymorphism and gastric cancer［J］.Biomedical Reports,2017,7(5):469-473.
[5]Jamsheed J,Rashid M,Julka PK,et al.Association of p53 and MDM2 in the development and progression of non-small cell lung cancer［J］.Tumour Bio，2015,36(7):5425-5432.
[6] Yadav P,Masroor M,Tanwer K,et al.Clinical significance of TP53(R72P) and MDM2(T309G) polymorphism in breast cancer patients［J］.Clin Trans Oncology,2016,18(7):728-734．
[7] Jainagul I,Elnura T,Nazira A,et al. The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females［J］.BMC Cancer,2017,17(1):758．
[8] Ding H,Dai Y,Ning ZY,et al.Murine double minute 2 SNP T309G poly- morphism and urinary tract cancer［J］.Medcine,2016,95(12):2941．
[9] Tian XD,Wang B,Guo JT,et al.The MDM2 T309G polymorphism and risk of lung cancer:An updated meta analysis of 10,186 cases and 14,155 controls［J］.Panminerva Medical，2016,58(4):341-348．
[10] Chen JY,Yang H,Wen J,et al.Association between positive murine double minute 2 expression and clinicopathological characteristics of esophageal squamous cell carcinoma:A Meta-analysis［J］．Diseases of the Esophagus，2016,29(7):856-863．
[11]Xue ZW,Zhu XL,Teng YC.Relationship between murine double minute 2(MDM2) T309G polymorphism and endometrial cancer risk:A Meta-ananlysis［J］.Medical Sci Monitor,2016(22):3186-3190．
[12]Bin X,Zheng X,Gong C,et al.Association between polymorphisms of TP53 and MDM2 and prostate cancer risk in Southern Chinese［J］. Cancer Genetics and Cytogenetics,2010(202):76-81.
[13]Liv B Gansmo,Stian Knappskog,Pal Romundstad,et al.Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon［J］．International Journal of Cancer，2015(137):96-103．
[14] Yang J,Gao W,Song NH,et al.The risk,degree of malignancy and clinical progression of prostate cancer associated with the MDM2 T309G polymorphism:A Meta-analysis［J］.Asian Journal of Andrology,2012,14（5):726-731.

Memo

Memo:
西安市科技计划项目［编号：2017114SF/YX008(11)］；陕西省卫生健康科研基金项目（编号:2018D031）
Last Update: 2019-12-26