|Table of Contents|

The expression of LKB1 gene in acute leukemia and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
632-635
Research Field:
Publishing date:

Info

Title:
The expression of LKB1 gene in acute leukemia and its clinical significance
Author(s):
Zhang Ming; Li Mengqi; Jiang Huinan; Li Jia; Liu Zhuogang
Department of Hematology,Shengjing Hospital of China Medical University，Liaoning Shenyang 110000,China.
Keywords:
LKB1; acute leukemia; Western blot
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2019.04.022
Abstract:
Objective:To observe the protein expression of LKB1 in different kinds of acute leukemia,and study the relationship between LKB1 gene and the occurrence and development of acute leukemia.Methods:32 samples of leukemia patients were retrospectively selected into the present study.All these patients came from the cytology department of our hospital from June 2016 to June 2017.As the control group,at the same time,we selected the patients without malignancy of hematological.Western blot was used to test the expression of LKB1 in the two groups.Results:There was no significant correlation between LKB1 gene expression and age or gender.Of the 12 cases in the control group,12 cases of LKB1 were positive.The leukemia group was divided into three groups according to the disease type.There were 19 cases of acute nonlymphocytic leukemia(ANLL),of which LKB1 was positive in 9 cases.Compared with the control group,the difference was statistically significant（P＜0.05）.Among 8 cases of acute B-lymphocytic leukemia（B-ALL）,LKB1 was positive for 3 cases.Compared with the control group,the difference was statistically significant（P＜0.05）.Among 5 cases of acute T-lymphocytic leukemia（T-ALL）,LKB1 was positive for 5 cases.Compared with the control group,the difference was not statistically significant（P＞0.05）.The results showed that the CR1 rate and CR2 rate were both higher in LKB1+ group than LKB1- group,and the proportion of patients with recurrent refractory was lower than LKB1- group.Conclusion:There was a significant correlation between LKB1 gene and the occurrence of acute nonlymphocytic leukemia and acute B-lymphocytic leukemia.The pathogenesis of acute T lymphocytic leukemia may be different from the previous two.LKB1 negative may indicate worse prognosis.

References:

［1］Shorning BY,Clarke AR.LKB1 loss of function studied in vivo［J］.FEBS Lett,2011,585(7):958-966.
［2］Hematology Conference of the Chinese Medical Association.Guidelines for the diagnosis and treatment of acute myeloid leukemia (relapsed and refractory) in China (2011 edition)［J］.Chinese Journal of Hematology,2011,32(12):887-888．［中华医学会血液学分会.急性髓系白血病(复发难治性)中国诊疗指南(2011版)［J］.中华血液学杂志，2011,32(12):887-888.］
［3］Pan J,Wang TT,Liu J,et al.Mutation of LKB1 gene in sporadic Peutz-Jeghers syndrome［J］.Chinese Journal of Cancer Surgery,2012,4(3):142-144,158.［潘键,王婷婷,刘炯,等.散发性Peutz-Jeghers综合征患者LKB1基因突变情况［J］.中国肿瘤外科杂志,2012,4(3):142-144,158.］
［4］Gan RY,Li HB.Recent progress on liver kinase B1(LKB1):expression,regulation,downstream signaling and cancer suppressive function ［J］.Int J Mol Sci,2014,15(9):16698-16718.
［5］Herrmann JL,Byekova Y,Elmets CA,et al.Liver kinase B1(LKB1) in the pathogenesis of epithelial cancer［J］.Cancer Lett,2011,306:1-9.
［6］Kan JY,Yen MC,Wang JY,et al.Nesfatin-1/Nucleobindin-2 enhances cell migration,invasion,and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer［J］.Oncotarget,2016,7(21):31336-31349.
［7］Xiao P,Sun LL,Wang J,et al.LKB1 gene inactivation does not sensitize non-small cell lung cancer cells to mTOR inhibitors in vitro［J］.Acta Pharmacol Sin,2015,6(1):10-11.
［8］Dupuy F,Griss T,Blagih J,et al.LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer［J］.Cancer Metab,2013,1(1):18．
［9］Fogarty S,Ross FA,Vara Ciruelos D,et al.AMPK causes cell cycle arrest in LKB1-Deficient cells via activation of CAMKK2［J］.Mol Cancer Res,2016,14(8):683-695.
［10］Jiang S,Chen R,Yu J,et al.Clinical significance and role of LKB1 in gastric cancer［J］.Mol Med Rep,2016,13(1):249-256.
［11］Morton JP,Jamieson NB,Karim SA,et al.LKB1 haploinsufficiency Cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest［J］.Gastroenterology,2010,139(2):586-597.
［12］Gill RK,Yang SH,Meerzaman D,et al.Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer［J］.Oncogene,2011,30(35):3784-3791.
［13］Wu CC,Wu DW,Lin YY,et al.Hepatitis B virus X protein represses LKB1 expression to promote tumor progression and poor postoperative outcome in hepatocellular carcinoma［J］.Surgery,2018,163(5)：1040-1046.
［14］Li NS,Zou JR,Lin H,et al.LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells［J］.Tumour Biol,2016,37(6):8249-8258.
［15］Vlachostergios PJ,Oikonomou KG,Gibilaro E,et al.Elevated lactic acid is a negative prognostic factor in metastatic lung cancer［J］.Cancer Biomark,2015,15(6):725-734.
［16］Shan T,Zhang P,Xiong Y,et al.Lkb1 deletion upregulates Pax 7 expression through activating Notch signaling pathway in myoblasts［J］.Int J Biochem Cell Biol,2016,76:31-38.
［17］Wang Z,Wang N,Liu P,et al.AMPK and cancer［J］.EXS,2016,107:203-226.
［18］Kuang X,Liu C,Fang J,et al.The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development［J］.FEBS Lett,2016,590(14):2076-2085.
［19］Li TY,Liu DN,Lei X,et al.Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway［J］.Biochemical and Biophysical Research Communications,2017,482（4）:1033-1041.
［20］Gungor-Ordueri NE,Tang EI,Celik-Ozenci C,et al.Ezrin is an actin binding protein that regulates sertoli cell and spermatid adhesion during spermatogenesis［J］.Endocrinology,2014,155:3981-3995.
［21］eliktas M,Tanaka I,Chandra Tripathi S,et al.Role of CPS1 in cell growth,metabolism,and prognosis in LKB1-inactivated lung adenocarcinoma［J］.J Natl Cancer Inst,2017,109(3):1-9.

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