|Table of Contents|

Effectiveness of FLAG regimen and MEA regimen for refractory and relapsed acute myeloid leukemia:A Meta-analysis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
636-640
Research Field:
Publishing date:

Info

Title:
Effectiveness of FLAG regimen and MEA regimen for refractory and relapsed acute myeloid leukemia:A Meta-analysis
Author(s):
Liu Xiangxiang; Zhang Tao; Wang Jianhong; Zhang Na; Hao Caixia; Lu Yingjuan; Guo Huayan; Duan Xiaohui;  Liang Rong
Department of Hematology,Xijing Hospital,the Air Force Military Medical University,Shaanxi Xi'an 710032,China.
Keywords:
FLAG; MEA; refractory and relapse acute myeloid leukemia(RRAML); Meta-analysis; systematic review; randomized controlled trial
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2019.04.023
Abstract:
Objective:To systematically evaluate the effectiveness and adverse reaction of FLAG and MEA in the treatment of refractory and relapse acute myeloid leukemia(RRAML).Methods:Such databases as PubMed,Cochrane Library,Web of Science,VIP,WanFang Data,CNKI,CBM were searched to collect the randomized controlled trials(RCTs) on FLAG and MEA in treating refractory and relapse acute myeloid leukemia.Document selection and data fetch and the quality of included studies was evaluated by two reviewers in-dependently,and then Meta-analyses were performed using Review Manager 5.0 software.Results:A total of six studies involving 299 patients were included.Results of Meta-analyses showed that when FLAG and MEA were used in the treatment of refractory and relapse acute myeloid leukemia,significant differences were found in the total effective rate (RR=1.98,95%CI:1.21 to 3.24,P=0.006),but no significant difference was found in complete remission (RR=1.49,95%CI：0.92 to 2.43,P=0.11) and partial remission (RR=1.38,95%CI:0.82 to 2.32,P=0.23).And the fungal infection rate after treatment were also significant differences (RR=2.17,95%CI:1.09 to 4.31,P=0.03).Conclusion:In the total effective rate of treatment for refractory and relapse acute myeloid leukemia,the FLAG regimen is superior to MEA regimen,but the fungal infection rate was also higher.However,all these findings should be further confirmed with more large sample and well-designed RCTs.

References:

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