|Table of Contents|

Quantitative DCE-MRI to evaluate the neoadjuvant radioc hemotherapy effect in patients with locally advanced rectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
626-631
Research Field:
Publishing date:

Info

Title:
Quantitative DCE-MRI to evaluate the neoadjuvant radioc hemotherapy effect in patients with locally advanced rectal cancer
Author(s):
Tan Jing; Zhang Ya; Wang Hongbo; Jin Yan; Feng Yusen; Ding Yingying
Department of Radiology,The Tumor Hospital of Yunnan Province，Third Affiliatied Hospital of Kunming Medical Univercity，Yunnan Kunming 650118,China.
Keywords:
colorectal cancer; locally advanced; neoadjuvant therapy; magnetic resonance imaging; dynamic contrast enhanced-magnetic resonance imaging
PACS:
R735.3+7
DOI:
10.3969/j.issn.1672-4992.2019.04.021
Abstract:
Objective:To prospectively investigate the changes of quantitative parameters in dynamic contrast enhanced-MRI (DCE-MRI) in locally advanced rectal cancer patients before and after the neoadjuvant radiochemotherapy.Methods:Thirty-four patients with locally advanced rectal cancer (in stage T3,T4) under-went DCE-MRI before and 1 week after neoadjuvant radiochemotherapy.The patients were classified into a reaction group (CR include mrTRG1、mrTRG2 and mrTRG3) or a non-CR(include mrTRG4 and mrTRG5) group according to the (TRG).The following DCE-MRI quantitative parameters values (Ktrans,Kep,Ve) were measured and compared between the CR and non-CR groups before and after treatment.Results:There were 18 and 16 patients in CR and non-CR groups.The Ktrans ［(1.48±0.80)/min,(0.88±0.45)/min,P＜0.05］ and Kep ［(3.29±1.25)/min,(2.12±1.18)/min,P＜0.05］ were lower than those in prior-treatment in total patients.Before neoadjuvant radiochemotherapy,the Ktrans and Ve were higher in CR group［(1.93±0.81)/min,0.59±0.27］ than those in non-CR group ［(0.82±0.49)/min,0.35±0.16］,and these differences were statistically significant.After neoadjuvant radiochemotherapy,the changed value of Ktrans ［(-1.11±66)/min］ and changed value of Ve (0.21±0.27) between the two groups were just reversed.Conclusion:Quantitative parameters of DCE-MRI provided a new noninvasive way to reflect the changes of hemodynamics in locally advanced rectal cancer patients with neoadjuvant radiochemotherapy.

References:

［1］Wang YN,Shi GF,Du H.Comparison of MSCT and MRI in preoperative staging of colorectal cancer［J］.Chinese Medical Imaging Technology,2011,4(27):772-775.［王亚宁，时高峰，杜煌.比较MSCT与MRI在结直肠癌术前分期诊断中的价值［J］.中国医学影像技术,2011,4(27):772-775.］
［2］Cong JC,Chen CS,Ma MX,et al.Effect of neoadjuvant therapy on quality of life in patients with locally advanced rectal cancer［J］.Chinese Journal of General Surgery 2014,23(4):451-457.［丛进春,陈春生,马明星,等.新辅助治疗对局部进展期直肠癌患者的生活质量的影响［J］.中国普通外科杂志,2014,23(4):451-457.］
［3］Sun YS,Zhang XP,Tang L,et al.Comparative study of high resolution MRI signs and pathological T staging in local invasion of rectum［J］.Chinese Medical Imaging Technology,2009,25(3):465-468.［孙应实，张晓鹏，唐磊，等.直肠轴位局部浸润的高分辨MRI征象与病理学T分期的对照研究［J］.中国医学影像技术，2009,25(3):465-468.］
［4］T Anna,K Zygmunt,F Violetta,et al.The determination of VEGF and MVD,among patients with primary breast cancer［J］.Pathology Oncology Research Por,2008,14(2):137-144.
［5］SG Larsen,JN Wiig,HL Emblemsvaag,et al.Extended total mesorectal excision in locally advanced rectal cancer (T4a) and the clinical role of MRI-evaluated neo-adjuvant downstaging［J］ .Colorectal Disease the Official Journal of the,2009,11(7):759-767.
［6］Xie Yuen,Liao Jinyuan,Wang Zheng,et al.Relationship between DCE-MRI parameters and pathological staging in rectal cancer［J］.Chinese Journal of Oncology Prevention and Treatment,2017,9(06):482-485.［谢雨恩,廖锦元,王铮,等.直肠癌DCE-MRI参数与病理分期的相关性研究［J］.中国癌症防治杂志,2017,9(06):482-485.］
［7］Mandard AM,Dalibard F,Mandard JC,et al.Prognostic significance of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma.Clinicopathologic correlations［J］.Cancer-AM Cancer Soc,1994,73(11):2680-2686.
［8］Kim SH,Lee JY,Lee JM,et al.Apparent diffusion coefficient for evaluating tumour response to neoadjuvant chemoradiation therapy for locally advanced rectal cancer［J］ .European Radiology,2011,21(5):987-995.
［9］Kim SH,Lee JY,Hong SH,et al.Locally advanced rectal cancer:Added value of diffusion-weighted MR imaging in the evaluation of tumor response to neoadjuvant chemo- and radiation therpy［J］.Radiology,2009,253(1):116-125.
［10］Cheng Rong,Dou Weitao.The value of comprehensive use of MRI,DWI and DCE-MRI in clinical staging,diagnosis and treatment for rectal cancer［J］.Journal of Medical Imaging,2016,26(10):1851-1854.［程蓉,窦卫涛.MRI DWI及DCE-MRI综合使用对直肠癌临床分期与诊断价值［J］.医学影像学杂志,2016,26(10):1851-1854.］
［11］Li Lin,Wang Kai,Sun Xilin,et al.Parameters of dynamic contrast-enhanced MRI as imaging markers for angiogenesis in human breast cancer［J］.Progress in Morden Biomedicine,2016,16(14):2687-2691.［李琳,王凯,孙夕林,等.DCE-MRI参数与肿瘤新生血管的相关性的研究［J］.现代生物医学进展,2016,16(14):2687-2691.］
［12］Nougaret S,Rouanet P,Molinari N,et al.MR volumetric measurement of low rectal cancer helos predict tumor response and outcome after combined chemotherapy and radiation therapy［J］.Radiology,2012,263(2):409-418.
［13］Rosenkrantz AB,Padhani AJ,Achten E,et al.Optimal experimental design for diffusion kurtosis imaging［J］.Magn Reson Imaging,2015,42(5):1190-1202.
［14］MAGI Cancer,P Piedbois,P Rougier,et al.Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer.Meta-analysis Group In Cancer［J］.Journal of Clinical Oncology Official Journal,2010,16(1):301-308.
［15］P Vaupel,F Kallinowski,P Okunieff.Blood flow,oxygen and nutrient supply,and metabolic microenvironment of human tumors:A review［J］.Cancer Research,1989,49(23):6449-6465.
［16］S Bahri,JH Chen,RS Mehta,et al.Residual breast cancer diagnosed by MRI in patients receiving neoadjuvant chemotherapy with and without bevacizumab［J］.Annals of Surgical Oncology,2009,16(6):1619-1628.
［17］Wasser K,Sinn HP,Fink C,et al.Accuracy of tumor size measurement in breast cancer using MRI is influenced by histological regression induced by neoadjuvant chemotherapy［J］.European Radiology,2003,13(6):1213-1223.
［18］JM Wheeler,BF Warren,AC Jones,et al.Preoperative radiotherapy for rectal cancer:implications for surgeons,pathologists and radiologists［J］.British Journal of Surgery,1999,86(9):1108-1120.
［19］SC Partridge,JE Gibbs,Y Lu,et al.MRI measurements of breast tumor volume predict response to neoadjuvant chemotherapy and recurrence-free survival［J］.American Journal of Roentgenology,2005,184(6):1774-1781.
［20］MS Kwong,GG Chung,LJ Horvath,et al.Postchemotherapy MRI overestimates residual disease compared with histopathology in responders to neoadjuvant therapy for locally advanced breast cancer［J］.Cancer Journal,2006,12(3):212-221.
［21］Yang Xinyue,Xiao Xiaojuan,Lu Baolan,et al.Effectiveness of perfusion parameters of DCE-MRI in distinguishing different histological grades of rectal cancer:a meta-analysis［J］.Chinese Journal of Evidence-Based Medicine,2017,17(05):536-543.［杨心悦,肖晓娟,卢宝兰,等.DCE-MRI定量灌注参数鉴别直肠癌病理分级的Meta分析［J］.中国循证医学杂志,2017,17(05):536-543.］
［22］Yang Zhao,Du Xiaosong,Hou Lina,et al.Meta analysis of quantitative dynamic contrast-enhanced MRI for the assessment of neoadjuvant chemotherpy in breast cancer［J］.International Journal of Medical Radiology,2018,41(01):11-16.［杨钊,杜笑松,侯丽娜,等.DCE-MRI定量分析对乳腺癌新辅助化疗疗效评估价值的Meta分析［J］.国际医学放射学杂志,2018,41(01):11-16.］
［23］JS Lim,D Kim,SE Baek,et al.Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer［J］.European Radiology,2012,22(22):1693-1700.
［24］Y Li,N Rosen,C Arteaga.Targeted cancer therapies［J］.Bulletin Du Cancer,2011，30(1):1-4.
［25］JH Chen,S Bahri,RS Mehta,et al.Breast cancer:evaluation of response to neoadjuvant chemotherapy with 3.0 T MR imaging［J］.International Journal of Medical Radiology,2012,261(3):735-743.
［26］Wang XH,Peng WJ,Tang F,et al.Application of T2 * magnetic resonance perfusion imaging in monitoring the efficacy of neoadjuvant chemotherapy in breast cancer［J］.Journal of Applied Radiology,2010,26(9):1323-1327.［汪晓红,彭卫军,唐峰,等.T2*磁共振灌注成像监测乳腺癌新辅助化疗疗效的应用研究［J］.实用放射学杂志,2010,26(9):1323-1327.］
［27］V Roy,D Raphaela,B Geerard,et al.The accuracy of multi-detector row CT for the assessment of tumor invasion of the mesorectal fascia in primary rectal cancer［J］.Biochemical Journal,2008,33(5):604-610.
［28］Cooper RA,Carrington BM,Loncaster JA,et al.Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix［J］.Radiotherapy & Oncology Journal of the Europea,2000,57(1):53-59.
［29］K Jae-Hun,KC Kyo,P Byung Kwan,et al.Dynamic contrast-enhanced 3-T MR imaging in cervical cancer before and after concurrent chemoradiotherapy［J］.European Radiology,2012,22(11):2533-2539.
［30］SH Kim,JM Lee,SN Gupta,et al.Dynamic contrast-enhanced MRI to evaluate the therapeutic response to neoadjuvant chemoradiation therapy in locally advanced rectal cancer［J］.Journal of Magnetic Resonance Imaging,2014,40(3):730-737.

Memo

Memo:
-
Last Update: 1900-01-01