|Table of Contents|

Clinical efficacy of laparoscopic radical hepatectomy for hepatocellular carcinoma and its effect on NGF and MMP-13 level

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
611-615
Research Field:
Publishing date:

Info

Title:
Clinical efficacy of laparoscopic radical hepatectomy for hepatocellular carcinoma and its effect on NGF and MMP-13 level
Author(s):
Liang YutuanRong ZhenxiangMai XianqiangZhang Shaoling
Department of General Surgery,New Rongqi Hospital,Guangdong Foshan 528303,China.
Keywords:
laparoscopyradical hepatectomyprimary hepatocellular carcinomaliver function
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2019.04.017
Abstract:
Objective:To study the clinical efficacy of laparoscopic radical hepatectomy for hepatocellular carcinoma and its effect on NGF and MMP-13 level.Methods:From January 2012 to December 2016,65 patients with primary liver cancer in our hospital were treated with open hepatectomy (control group) and laparoscopic radical hepatectomy (observation group).Results:In the observation group,the operation time,the exhaust time,the extubation time,the absolute bed time and the time of hospitalization were shorter than those of the control group.After 3 d,MMP-13,ICAM-1,NGF,PⅢP,and the PCT level in the observation group were lower than that of the control group.The level of liver function index in the observation group was lower than that of the control group at 1 month after the operation,and the difference was statistically significant (P<0.05).With after one year's visit,the recurrence rate and metastasis rate of the patients in the observation group were 15.15% and 3.03%,and that in the control group were 28.13% and 12.50%,respectively.The recurrence rate and the metastasis rate in the observation group were lower than those in the control group,but there was no statistical difference between the two groups (P>0.05).Conclusion:Laparoscopic radical resection of liver cancer is more beneficial to promote the recovery of liver function than open hepatectomy.It can reduce the level of MMP-13 and NGF.The recovery is faster and the hospitalization time is short.However,there is no significant difference between the recurrence rate and metastasis rate.

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Memo

Memo:
佛山市医学类科技攻关项目(编号:2015AB001773)
Last Update: 1900-01-01