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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2019 04

Page:

615-618

Research Field:

Publishing date:

Info

Title:

Diagnostic value and clinical significance of blood coagulation and tumor marker in colorectal cancer

Author(s):

Wang Yuying¹; Zhu Xiaofeng¹; Xue Yuling¹; Wang Wei²

1.Guangzhou University of Chinese Medicine,Guangdong Guangzhou 510405,China；2.Department of Gastrointestinal Surgery,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Guangzhou 510120,China.

Keywords:

colorectal cancer; blood coagulation; carcinoembryonic antigen(CEA); carbohydrate antigen 19-9(CA19-9); diagnostic value

PACS:

R735.3+5;R735.3+7

DOI:

10.3969/j.issn.1672-4992.2019.04.018

Abstract:

Objective:To explore the diagnostic value and clinical significance of tumor marker and blood coagulation in colorectal cancer.Methods:The peripheral fibrinogen(FIB),CA19-9,CEA were detected in 84 colorectal cancer patients and in 80 non-tumor patients.Using Logistic regression and ROC curve analysis to assess the diagnostic value of various indicators.Results:The levels of FIB,CA19-9,CEA in colorectal cancer patients before surgery were significantly higher than those in non-tumor patients,and the differences were statistically significant(P＜0.05).Compared with colorectal cancer Ⅰ-Ⅱ,FIB,CA19-9,CEA levels were significantly higher in Ⅲ-Ⅳ patients,and the differences were statistically significant(P＜0.05).The level of FIB was consilient correlated with CEA,CA19-9 in colorectal cancer patients,Youden's index and the area under ROC curve(AUC) in colorectal cancer diagnosis were improved by combined detection of FIB,CA19-9,CEA.Conclusion:The detection of FIB,CA19-9,CEA before surgery can help to distinguish benign colorectal cancer and malignant colorectal diseases,and monitor thrombus formation,raise the diagnostic value and contribute to early diagnosis and treatment．

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Memo

Memo:

广东省科技计划项目（编号：2011B031700011）

Common functions

Last Update: 1900-01-01