|Table of Contents|

Expression and clinical significance of long non-coding RNA lucat1 in gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
607-611
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of long non-coding RNA lucat1 in gastric cancer
Author(s):
Yu GuilinLin JieZhao GuohuaAi FuluWang Yue
General Surgery Ward,Liaoning Cancer Hospital & Institute,China Medical University,Liaoning Shenyang 110042,China.
Keywords:
lucat1gastric cancerprognosissurvival
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2019.04.016
Abstract:
Objective:To investigate the expression level of long non-coding RNA (lncRNA) lung cancer associated transcript 1 (lucat1) in gastric cancer,and evaluate its prognostic value in gastric cancer.Methods:Gastric cancer cells and gastric epithelial cell were tested in this study.Cancer tissue as well as adjacent normal tissue from patients diagnosed with gastric cancer were also harvested in this study.Expression of lucat1 was measured by RT-PCR.ANOVA analysis was performed to evaluate the association between lucat1 and clinical manifestation of gastric cancer patients.K-M survival analysis was utilized to determine correlation of lucat1 expression with 5-year survival.Cox's proportional hazards regression models were applied to analyze the relationships between lucat1 and prognosis of gastric cancer patients.Results:Lucat1 was upregulated in gastric cancer tissues and cells compared with normal tissues and cell.Expression of lucat1 was closely associated with TNM stage of gastric cancer (P<0.05).Expression of lucat1 was negatively correlated with 5 -years survival rate.Lucat1 is an independent prognostic risk factor of gastric cancer.Conclusion:lncRNA lucat1 is upregulated in gastric cancer and is negatively associated with outcome of gastric cancer.

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Memo

Memo:
国家外专局2017年第一批引进境外技术管理人才项目计划(编号:20172100003)
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