|Table of Contents|

The difference of side-effects between exemestane and anastrozole in endocrine therapy of breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
574-579
Research Field:
Publishing date:

Info

Title:
The difference of side-effects between exemestane and anastrozole in endocrine therapy of breast cancer
Author(s):
Li NaDu YangfanLi KaiYan Shunchao
Department of Oncology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110022,China.
Keywords:
anastrozoleexemestaneendocrine therapyside effects
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2019.04.008
Abstract:
Objective:To explore the difference of side effects between nonsteroidal aromatase inhibitor anastrozole and steroidal aromatase inhibitor exemestane in breast cancer patients.Methods:Randomized controlled trials including side effects of exemestane and anastrozole were retrieved in the databases such as PubMed,Chinese knowledge resource pool,CNKI and Wanfang.RevMan 5.3 was used for Meta-analysis.Results:There are five studies were included.Meta-analysis results showed that there was no significant difference between anastrozole and exemestane in hot flashes,anemic,hypertension,and arthritis/joint pain.In hypertriglyceridemia,exemestane was nineteen percent lower than that of anastrozole (OR=0.81,95%CI:0.69~0.94,P=0.005),the difference was statistically significant.In hypercholesterolemia,exemestane was seventeen percent lower than that of anastrozole (OR=0.83,95%CI:0.76~0.92,P=0.000 3),the difference was statistically significant.Conclusion:Exemestane had less side effect than anastrozole in hypertriglyceridemia and hypercholesterolemia.Exemestane maybe a better choice for the patients who have high cholesterol,high triglyceride or other risk factors for cardiovascular disease.

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Memo

Memo:
National Natural Science Foundation of China(No.81302313);国家自然科学基金项目(编号:81302313);辽宁省自然科学基金指导计划(编号:20170540995);沈阳市中青年科技创新人才支持计划项目(编号:RC170545)
Last Update: 1900-01-01