|Table of Contents|

Immunomodulatory effect of honeysuckle decoction on patients with radiation esophagitis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
580-583
Research Field:
Publishing date:

Info

Title:
Immunomodulatory effect of honeysuckle decoction on patients with radiation esophagitis
Author(s):
Song ChangliangDu XuefeiYang QiongZhang ZhenjunWan LianggangYan JianjunXie Wenyao Zhang XiaohuiYang ZhiyongWang Yafei
Department of Oncology,Handan Central Hospital,Hebei Handan 056001,China.
Keywords:
radiation esophagitishoneysuckleimmune function
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2019.04.009
Abstract:
Objective:To observe the immunomodulatory effect of honeysuckle decoction on patients with radiation esophagitis.Methods:150 cases of esophageal cancer radiotherapy were randomly divided into control group and observation group,75 cases in each group.The control group was given the corresponding dose of dexamethasone.The observation group was treated with honeysuckle decoction on the basis of the treatment of the control group.Incidence of radiation esophagitis,incidence of the disease,inflammatory factors (TNF-α,IL-6,TGF-β1),immune factors (IgG,CRP,complement C3 and complement C4) and changes of lymphocyte subsets were compared between the two groups after radiotherapy.Results:The incidence of radioactive esophagitis in the observation group was lower than that of the control group(P<0.05),and the incidence of the disease was lower than that of the control group.The levels of inflammatory factors increased after radiotherapy in both groups.The levels of inflammatory factors in the observation group were lower than those in the control group(P<0.05),and the level of immune factor CRP was lower than that of the control group(P<0.05),the level of IgG and complement C3 was higher than that of the control group (P<0.05).The level of CD3+T,CD4+T and CD4+/CD8+ in the observation group was higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was better than that of the control group.Conclusion:Honeysuckle decoction can effectively inhibit the decrease of immune function caused by radiotherapy,enhance the level of immunity,and reduce the incidence of radiation esophagitis.

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Memo

Memo:
2018年度河北省医学科学研究重点课题计划项下课题(编号:20181697)
Last Update: 1900-01-01