|Table of Contents|

Expression and clinical significance of QKI-5 in clear cell renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
443-446
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of QKI-5 in clear cell renal cell carcinoma
Author(s):
Liu Qiang1; Yang Ying2; Wang Wenguang1; Zhang Hua2; Cai Ceng2; Bao Yongxing2; Wang Yujie1; Zhang Ruili1
1.Department of Urology；2.Department of Cancer Center，the First Affiliated Hospital of Xinjiang Medical University，Xinjiang Urumqi 830011，China.
Keywords:
QKI-5; clear cell renal cell carcinoma; prognosis
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2019.03.021
Abstract:
Objective：To compare the expression level of QKI-5 between clear cell renal cell carcinoma (ccRCC) and adjacent tissues and to analyze the relationship between the expression level of QKI-5 and the clinicopathology，and to investigate the association of QKI-5 and prognosis in patients with ccRCC.Methods：Through quantitative real-time polymerase chain reaction (qRT-PCR),we determined the expression of QKI-5 in 68 cases of ccRCC tissues and adjacent tissues and we analysed the relationship between QKI-5 expression and clinicapathology by paried t test.Kaplan-Meier method and multivariate survival analyses were performed to identify the relationship between QKI-5 expression and prognosis.Results：QKI-5 was down-regulated in ccRCC tissues （72.06%）and the QKI-5 expression in ccRCC tissues was correlated with T stage and G grade.Patients with higher QKI-5 expression exhibited better prognosis than those with lower QKI-5 expression （P=0.009）.In multivariate analysis，QKI-5 expression was positively associated with improved survival.Conclusion：QKI-5 was inhibited in ccRCC，and low QKI-5 expression was associated with poor prognosis.

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Memo

Memo:
新疆维吾尔自治区自然科学基金项目（编号：2016D01C334）
Last Update: 2018-12-29