|Table of Contents|

The expression and prognostic value of ERCC1 in colorectal cancer tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
447-451
Research Field:
Publishing date:

Info

Title:
The expression and prognostic value of ERCC1 in colorectal cancer tissues
Author(s):
Ou BaoqiZhao YongRong FengYan Wei
Department of Oncology,Lu'an Hospital Affiliated to Anhui Medical University,Anhui Lu'an 237000,China.
Keywords:
colorectal cancerERCC1adjuvant chemotherapyprognosis
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2019.03.022
Abstract:
Objective:To explore the prognostic value of nucleotide excision repair cross-complementation gene 1 (ERCC1) expression in patients receiving oxaliplatin adjuvant chemotherapy with colorectal cancer (CRC).Methods:A total of 84 patients undergoing mFOLFOX6 chemotherapy after radical resection of CRC from Lu'an Hospital Affiliated to Anhui Medical University from January 2011 to January 2013 were selected.The expression of ERCC1 in CRC tissues was evaluated by immunohistochemistry and the correlation between ERCC1 expression and prognosis was analyzed.Results:ERCC1 was highly expressed in 30 patients (35.7%).Kaplan-Meier curves showed a reduction in disease-free survival (DFS) and overall survival (OS) in CRC patients with high ERCC1 expression (P<0.001).Multivariate COX analysis showed that high expression of ERCC1 (DFS HR=4.645,95%CI:2.045~10.548,P<0.001.OS HR=4.898,95%CI:1.971~12.170,P<0.001) was a poor prognostic factor.Analysis of the correlation between ERCC1 expression and survival in similar subgroups was similar.Among the 16 patients with high expression and recurrence of ERCC1,liver and lung metastasis was 68.8% (11/16).In 10 patients with low expression of ERCC1 and recurrence,70.0% (7/10) of the patients had peritoneal metastasis.ERCC1 expression was significantly associated with the first recurrence pattern (P=0.006).Conclusion:ERCC1 expression can be used as an important indicator to evaluate the prognosis of CRC patients and may help predict the first relapse pattern after adjuvant chemotherapy in CRC patients.The prognostic value of ERCC1 expression needs further study.

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Memo

Memo:
卫生部医药卫生科技发展研究中心课题(编号:W2012FZ140)
Last Update: 2018-12-29