|Table of Contents|

Clinical effect of PEG-rhG-CSF in preventing neutropenia after biweekly dose-dense adjuvant chemotherapy in colon cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
440-443
Research Field:
Publishing date:

Info

Title:
Clinical effect of PEG-rhG-CSF in preventing neutropenia after biweekly dose-dense adjuvant chemotherapy in colon cancer
Author(s):
Zhang Yidan1Qiu Jianing2Du Cheng2Qu Shuxian2Liu Yuhui1Zheng Zhendong2Xie Xiaodong2
1.Chinese and Western Medicine Department of Oncology,Northeast International Hospital,Liaoning Shenyang 110000,China;2.Department of Oncology,the General Hospital of the Northern Theater of the Chinese People's Liberation Army,Liaoning Shenyang 110016,China.
Keywords:
colon cancerneutropeniaPEG-rhG-CSFdose-dense chemotherapy
PACS:
R735.3+5
DOI:
10.3969/j.issn.1672-4992.2019.03.020
Abstract:
Objective:To observe the efficacy and safety of polyethylene glycol recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia after adjuvant chemotherapy in colon cancer.Methods:In the General Hospital of the Northern Theater of the Chinese People's Liberation Army from December 2016 to September 2017,52 patients received a dose-dense regimen adjuvant chemotherapy for colon cancer patients.20 patients in the treatment group were subcutaneously injected with 6 mg PEG-rhG-CSF 24 hours after chemotherapy.The control group (32 cases) was not treated with PEG-rhG-CSF after chemotherapy.After discharge,according to the blood test results,the doctor decided whether to add recombinant human granulocyte colony stimulating factor (rhG-CSF).We mainly observed the frequency of rhG-CSF application again,the incidence of Ⅲ-Ⅳ degree neutropenia,the incidence of granulocytic fever,the incidence of reduction or delayed treatment and the quality of life (C-30 scale) due to granulocytopenia.Results:The patients in the treatment group did not need to be injected with rhG-CSF again,while 26 patients in the control group needed rhG-CSF,and 8 patients in the control group had Ⅲ-Ⅳ degree neutropenia and 2 patients had fever due to granulocytopenia,4 and 7 patients had decrement and delayed treatment because of granulocytopenia.The physiological status,social / family status and total score of the patients in the treatment group were significantly higher than those in the control group.The incidence of adverse reactions was similar between the two groups,and there was no statistical difference between the two groups.Conclusion:PEG-rhG-CSF can prevent the occurrence of Ⅲ-Ⅳ degree neutropenia after neoadjuvant chemotherapy,reduce delayed chemotherapy due to the occurrence of adverse reactions,without application of rhG-CSF treatment in patients with intermittent chemotherapy,and improve the safety and quality of life in patients.PEG-rhG-CSF has high safety and no obvious adverse reaction.

References:

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Last Update: 2018-12-29