|Table of Contents|

Recent development of anti-angiogenetic therapy in non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
165-171
Research Field:
Publishing date:

Info

Title:
Recent development of anti-angiogenetic therapy in non-small cell lung cancer
Author(s):
Yang JingruBi Minghong
The First Affiliated Hospital of Bengbu Medical College,Anhui Bengbu 233000,China.
Keywords:
non-small cell lung canceranti-angiogenesisvascular endothelial growth factortarget therapy
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2019.01.042
Abstract:
In non-small cell lung cancer(NSCLC),tumor angiogenesis is essential in the process of primary tumor growth,proliferation and metastasis.Angiogenesis inhibition has been identified as an important therapeutic strategy.The vascular endothelial growth factor(VEGF) as a key regulator in angiogenesis,was established as an important NSCLC therapeutic target.The clinical development of anti-angiogenic agents involved mainly two approaches:Monoclonal antibodies specifically target the VEGF ligands/receptors or small molecule tyrosine kinase inhibitor(TKI) that inhibit the downstream VEGF-receptors mediated signaling pathways.To date,two monoclonal antibodies,bevacizumab and ramucirumab,have been approved for the treatment of locally advanced or metastatic NSCLC when added to first or second-line standard chemotherapy.A variety of novel VEGFR-TKI have been widely evaluated in advanced NSCLC,but only anlotinib has been approved for third-line therapy for NSCLC in 2017 in China,nintedanib has also demonstrated a survival benefit when combined with chemotherapy in the second-line setting.This review will overview and summarize the landmark clinical data supporting the success of angiogenesis inhibitors for NSCLC.

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Last Update: 2018-11-30