|Table of Contents|

DENN/MADD domain containing 2D and non-small cell lung cancer-related research progress

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
171-174
Research Field:
Publishing date:

Info

Title:
DENN/MADD domain containing 2D and non-small cell lung cancer-related research progress
Author(s):
Wang YanXu Guangquan
Thoracic Surgery 2 Ward,The Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150081,China.
Keywords:
DENN/MADD domain containing 2Dnon-small cell lung cancerexpression of genes
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2019.01.043
Abstract:
In recent years,researches showed that over expression of DENN/MADD domain containing 2D(DENND2D),a tumor suppressor-like gene,significantly suppressed the proliferation of tumor cells in vitro and in vivo by inducing apoptosis.The mechanism is that DENND2D increases cleaved PARP expression by cutting PARP,and competitively inhibits the binding of MADD to the tumor cell death domain.In the meantime,downregulation of DENND2D in non-small cell lung cancer(NSCLC) cell was found.This low expression is associated with loss of the short arm on chromosome 1 of the tumor cell,the translation of DENND2D mRNA by microRNA-522 and the possible hypermethylation of the DENND2D promoter.

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Last Update: 2018-11-30