|Table of Contents|

Research on the relationship between breast cancer,hypoxia and adipose tissue

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
161-165
Research Field:
Publishing date:

Info

Title:
Research on the relationship between breast cancer,hypoxia and adipose tissue
Author(s):
Wang WenzhengLi Zhigao
Department of Breast Surgery,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150086,China.
Keywords:
breast cancerhypoxiaadipose tissue
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2019.01.041
Abstract:
Breast cancer is the most common malignancy of women.The development of breast cancer cells is linked with hypoxia.The hypoxia-induced factor-1α(HIF-1α) influences metastasis through neovascularization.Hypoxia seems to decrease the responsiveness to hormonal treatment due to loss of estrogen receptors(ERs).Obesity is discussed to increase hypoxia in adipose tissues,which promotes a favorable environment for tumor cells in mammary fat tissue,whereas,tumor cells profit from good oxygen supply and are influenced by its deprivation as target regions within tumors show.This review gives an overview of the current state on research of hypoxia and breast cancer in human adipose tissue.

References:

[1]James FR,Wootton S,Jackson A,et al.Obesity in breast cancer-what is the riks factor[J]?Eur J Cancer,2015,51(6):705-720.
[2]Khodari W,Sedrati A,Naisse I,et al.Impact of loco-regional treatment on metastatic breast cancer outcome:A review[J].Crit Rev Oncol Hematol,2013,87(1):69-79.
[3]Calle EE,Rodriguez C,Walker-Thurmond K,et al.Overweight,obesity,and mortality from cancer in a prospectively studied cohort of U.S.adults[J].N Engl J Med,2003,348(17):1625-1638.
[4]Calle EE,Kaaks R.Overweight,obesity and cancer:Epidemiological evidence and proposed mechanisms[J].Nat Rev Cancer,2004,4(8):579-591.
[5]Renehan AG,Tyson M,Egger M,et al.Body-mass index and incidence of cancer:A systematic review and Meta-analysis of prospec-tive observational studies[J].Lancet,2008,371(9612):569-578.
[6]Wiseman M.The second world cancer research fund/American institute for cancer research expert report.Food,nutrition,physical activity,and the prevention of cancer:A global perspective[J].Proc Nutr Soc,2008,67(3):253-256.
[7]Vainio H,Kaaks R,Bianchini F.Weight control and physical activity in cancer prevention:International evaluation of the evidence[J].Eur J Cancer Prev,2002,11(2):94-100.
[8]Reeves GK,Pirie K,Beral V,et al.Cancer incidence and mortality in relation to body mass index in the million women study:Cohort study[J].BMJ,2007,335(7630):1134.
[9]Wolin KY,Carson K,Colditz GA.Obesity and cancer[J].Oncologist,2010,15(6):556-565.
[10]Ma J,Li H,Giovannucci E,et al.Prediagnostic body mass index,plasma C-peptide concentration,and prostate cancer-spe-cific mortality in men with prostate cancer:A long-term survival analysis[J].Lancet Oncol,2008,9(11):1039-1047.
[11]De Pergola G,Silvestris F.Obesity as a major risk factor for cancer[J].J Obes,2013,2013:291546.
[12]Divella R,De Luca R,Abbate I,et al.Obesity and cancer:The role of adipose tissue and adipo-cytokines-induced chronic inflammation[J].J Cancer,2016,7(15):2346-2359.
[13]Spindler SR.Rapid and reversible induction of the longevity,anticancer and genomic effects of caloric restriction[J].Mech Ageing Dev,2005,126(9):960-966.
[14]Pallavi R,Giorgio M,Pelicci PG.Insights into the beneficial effect of caloric/dietary restriction for a healthy and prolonged life[J].Front Physiol,2012,3:318.
[15]Imayama I,Ulrich CM,Alfano CM,et al.Effects of a caloric restriction weight loss diet and exercise on inflammatory biomark-ers in overweight/obese postmenopausal women:A randomized controlled trial[J].Cancer Res,2012,72(9):2314-2326.
[16]Semenza GL.Hypoxia-inducible factors in physiology and medicine[J].Cell,2012,148(3):399-408.
[17]Vaupel P,Hockel M,Mayer A.Detection and characterization of tumor hypoxia using PO2 histography[J].Antioxid Redox Signal,2007,9(8):1221-2335.
[18]Semenza GL.Advances in cancer biology and therapy[J].J Mol Med(Berl),2013,91(4):409.
[19]Cairns R,Papandreou I,Denko N.Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment[J].Mol Cancer Res,2006,4(2):61-70.
[20]Guppy M.The hypoxic core:A possible answer to the cancer paradox[J].Biochem Biophys Res Commun,2002,299(4):676-680.
[21]Lum JJ,Bui T,Gruber M,et al.The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis[J].Genes Dev,2007,21(9):1037-1049.
[22]Lopez-Lazaro M.The warburg effect:Why and how do cancer cells activate glycolysis in the presence of oxygen[J]?Anticancer Agents Med Chem,2008,8(3):305-312.
[23]Milane L,Duan Z,Amiji M.Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning[J].Cancer Cell Int,2011,11:3.
[24]Vaapil M,Helczynska K,Villadsen R,et al.Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells[J].PLoS One,2012,7(9):e46543.
[25]Hosogai N,Fukuhara A,Oshima K,et al.Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation[J].Diabetes,2007,56(4):901-911.
[26]Ye J,Gao Z,Yin J,et al.Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice[J].Am J Physiol Endocrinol Metab,2007,293(4):E1118-1128.
[27]Fridlyand LE,Philipson LH.Reactive species and early manifestation of insulin resistance in type 2 diabetes[J].Diabetes Obes Metab,2006,8(2):136-145.
[28]Gehmert S,Gehmert S,Bai X,et al.Limitation of in vivo models investigating angiogenesis in breast cancer[J].Clin Hemorheol Microcirc,2011,49(1-4):519-526.
[29]Yao-Borengasser A,Monzavi-Karbassi B,Hedges RA,et al.Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells[J].Oncol Rep,2015,33(6):2689-2694.
[30]Seifert A,Taubert H,Hombach-Klonisch S,et al.TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions[J].Int J Oncol,2009,35(2):417-424.
[31]Denzel MS,Hebbard LW,Shostak G,et al. Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer[J].Clin Cancer Res,2009,15(10):3256-3264.
[32]Gatterer H,Haacke S,Burtscher M,et al.Normobaric intermittent hypoxia over 8 months does not reduce body weight and metabolic risk factors-a randomized,single blind,placebo-controlled study in normobaric hypoxia and normobaric sham hypoxia[J].Obes Facts,2015,8(3):200-209.
[33]Mantzoros C,Petridou E,Dessypris N,et al.Adiponectin and breast cancer risk[J].J Clin Endocrinol Metab,2004,89(3):1102-1107.
[34]Chen DC,Chung YF,Yeh YT,et al.Serum adiponectin and leptin levels in Taiwanese breast cancer patients[J].Cancer Lett,2006,237(1):109-114.
[35]Pahlman S,Lund LR,Jogi A.Differential HIF-1alpha and HIF-2alpha expression in mammary epithelial cells during fat pad invasion,lactation,and involution[J].PLoS One,2015,10(5):e0125771.
[36]Schwab LP,Peacock DL,Majumdar D,et al.Hypoxia-inducible factor 1alpha promotes primary tumor growth and tumor-initiating cell activity in breast cancer[J].Breast Cancer Res,2012,14(1):R6.
[37]Galindo-Hernandez O,Villegas-Comonfort S,Candanedo F,et al.Elevated con-centration of microvesicles isolated from peripheral blood in breast cancer patients[J].Arch Med Res,2013,44(3):208-214.
[38]Chaturvedi P,Gilkes DM,Takano N,et al.Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment[J].Proc Natl Acad Sci USA,2014,111(20):E2120-2129.
[39]Luo W,Chang R,Zhong J,et al.Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression[J].Proc Natl Acad Sci USA,2012,109(49):E3367-3376.
[40]Garayoa M,Martínez A,Lee S,et al.Hypoxia-inducible factor-1(HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation:A possible promotion mecha-nism of carcinogenesis[J].Mol Endocrinol,2000,14(6):848-862.
[41]Chang J,Erler J.Hypoxia-mediated metastasis[J].Adv Exp Med Biol,2014,772:55-81.
[42]Saggar JK,Yu M,Tan Q,et al.The tumor microenvironment and strategies to improve drug distribution[J].Front Oncol,2013,3:154.
[43]Ceradini DJ,Kulkarni AR,Callaghan MJ,et al.Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1[J].Nat Med,2004,10(8):858-864.
[44]Semenza GL.HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations[J].J Clin Invest,2013,123(9):3664-3671.
[45]Aalders KC,Tryfonidis K,Senkus E,et al.Anti-angiogenic treatment in breast cancer:Facts,successes,failures and future perspectives[J].Cancer Treat Rev,2017,53:98-110.
[46]Hu Y,Liu J,Huang H.Recent agents targeting HIF-1alpha for cancer therapy[J].J Cell Biochem,2013,114(3):498-509.
[47]Cleator S,Heller W,Coombes RC.Triple-negative breast cancer:Therapeutic options[J].Lancet Oncol,2007,8(3):235-244.
[48]Xiang L,Gilkes DM,Chaturvedi P,et al.Ganetespib blocks HIF-1 activity and inhibits tumor growth,vascularization,stem cell maintenance,invasion,and metastasis in orthotopic mouse models of triple-negative breast cancer[J].J Mol Med(Berl),2014,92(2):151-164.
[49]Liapis V,Zinonos I,Labrinidis A,et al.Anticancer efficacy of the hypoxia-activated prodrug evofosfamide(TH-302) in osteolytic breast cancer murine models[J].Cancer Med,2016,5(3):534-545.
[50]Samanta D,Gilkes DM,Chaturvedi P,et al.Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells[J].Proc Natl Acad Sci USA,2014,111(50):E5429-5438.
[51]Moore SC,Lee IM,Weiderpass E,et al.Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults[J].JAMA Intern Med,2016,176:816-825.
[52]Cummings SR,Tice JA,Bauer S,et al.Prevention of breast cancer in postmenopausal women:Approaches to estimating and reducing risk[J].J Natl Cancer Inst,2009,101(6):384-398.
[53]Jones LW,Viglianti BL,Tashjian JA,et al.Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer[J].J Appl Physiol(1985),2010,108(2):343-348.
[54]Holick CN,Newcomb PA,Trentham-Dietz A,et al.Physical activity and survival after diagnosis of invasive breast cancer[J].Cancer Epidemiol Biomarkers Prev,2008,17(2):379-386.
[55]Hardman WE,Sun L,Short N,et al.Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogen-esis[J].Cancer Cell Int,2005,5(1):12.
[56]Myrte C,Elisabeth A,Diede Verlaan,et al.The mechanisms and effects of physical activity on breast cancer[J].Clinical Breast Cancer,2017,17(4):272-278.

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Last Update: 2018-11-30