|Table of Contents|

Research progress of exosomes in tumor cells and clinical application

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
945-950
Research Field:
Publishing date:

Info

Title:
Research progress of exosomes in tumor cells and clinical application
Author(s):
Zhang Qianjing1; 2; 3; 4; Di Cuixia1; 2; 3; Chen Yuhong1; 2; 3; 4; Yang Shifeng5; Wang Yupei1; 2; 3; 4; Liu Yang1; 2; 3; Zhang Hong1; 2; 3
1.Institute of Modern Physics,Chinese Academy of Sciences，Gansu Lanzhou 730000，China;2.Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences，Gansu Lanzhou 730000，China;3.Key Laboratory of Heavy Ion Radiation Medicine of
Keywords:
exosomes; tumor; drug carrier; drug resistance; radiotherapy; chemotherapy
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2018.06.033
Abstract:
Exosomes are nanoscale vesicles with a diameter of 40 to 130 nm,and are important cell intercellular communication molecules containing a large amount of protein,nucleic acid and lipid.Exosomes are not only important for tumor immunity,tumor invasion and metastasis and tumor resistance,but also has important value in the diagnosis and treatment of tumor.The definition,derivation and formation of exosomes are introduced in this article.In addition,it detailedly summarize the ways of extracting exosomes.Profound discussion about the clinical application of exosomes on drug carrier,radiotherapy,chemotherapy,and drug resistance study are given in final.This article aims at providing new direction of research to the molecular mechanism and clinical study of exosomes.

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Memo

Memo:
National Natural Science Foundation of China（No.U1432248，No.U1632270）；国家自然科学基金联合基金重点项目（编号：U1432248，U1632270）；National Natural Science Foundation of China（No.11675234,No.11575262）；国家自然科学基金面上项目（编号：11675234,11575262）；科技部国家重点研发项目（编号：2016YFC0904600）
Last Update: 2018-01-29