［1］ Siegel R,Naishadham D,Jemal A.Cancer statistics［J］.CA Cancer J Clin，2012，62:10-29.
［2］Ahn S,Cho J,Sung J,et al.The prognostic significance of tumor-associated stroma in invasive breast carcinoma［J］.Tumour Biol,2012,33:1573-1580.
［3］Limame R,de Beeck KO,Van Laere S,et al.Expression profiling of migrated and invade breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer［J］.Oncoscience,2014,1:69-81.
［4］ Ishibashi M,Moriyoshi K,Sasai Y,et al.Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system［J］.EMBO J,1994,13:1799-1805.
［5］ Liu ZH,Dai XM,Du B,et al.Hes1:A key role in stemness,metastasis and multidrug resistance［J］.Cancer Biol Ther,2015,16(3):353-359.
［6］Sang L,Roberts JM,Coller HA.Hijacking HES1:How tumors co-opt the anti-differentiation strategies of quiescent cells［J］.Trends Mol Med,2010,16:17-26.
［7］ Tian C,Zheng G,Cao Z,et al.Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment［J］.Cell Cycle,2013,12:322-331.
［8］ Iso T,Kedes L,Hamamori Y.HES and HERP families:Multiple effectors of the notch signaling pathway［J］.J Cell Physiol,2003,194:237-255.
［9］ Ingram WJ,McCue KI,Tran TH,et al.Sonic hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signaling［J］.Oncogene,2008,27:1489-1500.
［10］Stockhausen MT,Sjolund J,Axelson H.Regulation of the notch target gene hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells［J］.Exp Cell Res,2005,310:218-228.
［11］Curry CL,Reed LL,Golde TE,et al.Gamma secretase inhibitor blocks notch activation and induces apoptosis in Kaposi's sarcoma tumor cells［J］.Oncogene,2005,24:6333-6344.
［12］Rani A,Greenlaw R,Smith RA,et al.HES1 in immunity and cancer［J］.Cytokine Growth Factor Rev,2016,30:113-117.
［13］Davis RL,Turner DL.Vertebrate hairy and enhancer of split related proteins:Transcriptional repressors regulating cellular differentiation and embryonic patterning［J］.Oncogene,2001,20:8342-8357.
［14］Paroush Z,Finley RL Jr,Kidd T,et al.Groucho is required for drosophila neurogenesis,segmentation,and sex determination and interacts directly with hairy-related bHLH proteins［J］.Cell,1994,79:805-815.
［15］Zhang Y,Xu W,Guo H,et al.NOTCH1 signaling regulates self-renewal and platinum chemoresistance of cancer stem-like cells in human non-small cell lung cancer［J］.Cancer Res,2017,77(11):3082-3091.
［16］Goto N,Ueo T,Fukuda A,et al.Distinct roles of HES1 in normal stem cells and tumor stem-like cells of the intestine［J］.Cancer Res,2017,77(13):3442-3454.
［17］Wang X,Fu Y,Chen X,et al.The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance:A retrospective clinical study［J］.J Cancer Res Clin Oncol,2010,136:989-996.
［18］Cenciarelli C,Marei HE,Zonfrillo M,et al.The interference of Notch1 target Hes1 affects cell growth,differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets［J］.Oncotarget,2017,8(11):17873-17886.
［19］Hidalgo-Sastre A,Brodylo RL,Lubeseder-Martellato C,et al.Hes1 controls exocrine cell plasticity and restricts development of pancreatic ductal adenocarcinoma in a mouse model［J］.Am J Pathol,2016,186(11):2934-2944.
［20］Wang SC,Lin XL,Wang HY,et al.HES1 triggers epithelial-mesenchymal transition(EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway［J］.Oncotarget,2015,6:36713-36730.
［21］Yu He，Zhou Ping，Li Dan，et al.Expression and prognostic value of Notch3 and HES1 in non-small cell lung cancer［J］.Modern Oncology,2017,25(07):1043-1047.
［22］Gao F,Zhang YQ,Wang SC,et al.Hes1 is involved inthe self-renewal and tumourigenicity of stem-like cancercells in colon cancer［J］.Sci Rep,2014,4:3963.
［23］Yuan R,Ke J,Sun L,et al.HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer［J］.Clin Exp Metastasis,2015,32(2):169-179.
［24］Orzechowska M,Jedroszka D,Bednarek AK.Common profiles of Notch signaling differentiate disease-free survival in luminal type A and triple negative breast cancer［J］.Oncotarget,2017,8(4):6013-6032.
［25］Bennani-Baiti IM,Aryee DN,Ban J,et al.Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma［J］.J Pathol,2011,225:353-363.
［26］Wall DS,Mears AJ,McNeill B,et al.Progenitor cell proliferation in the retina is dependent on notch-independent sonic hedgehog/Hes1 activity［J］.J Cell Biol,2009,184:101-112.