|Table of Contents|

Expression of miRNA-25 and miRNA-143 in esophageal squamous cell cancer and their relation with clinical pathology

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 06
Page:
868-871
Research Field:
Publishing date:

Info

Title:
Expression of miRNA-25 and miRNA-143 in esophageal squamous cell cancer and their relation with clinical pathology
Author(s):
Huang Tao1; Zhou Bin2; Liu Weiliang1; Wang Yong1; Xu Jianhua1; Zhang Wei1
1.Department of Thoracic Surgery,Hanzhong 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University,Shaanxi Hanzhong 723000,China;2.Department of Thoracic Surgery,The Second Affiliated Hospital of Xi'an Jiaotong University Medical College,S
Keywords:
miRNA-25; miRNA-143; esophageal squamous cell carcinoma(ESCC); Real time-PCR
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2018.06.013
Abstract:
Objective:To analyze the relationship between miRNA-25 and miRNA-143 expression quantity in esophageal squamous cell carcinoma(ESCC) and their pathological features.Methods:Adopting the Real time-PCR method to detect 65 cases of ESCC tissues and the expression quantity of normal esophageal tissue of the miRNA-25 and miRNA-143,also analyze the relationship between their expression quantity and clinical pathological features.Results:The miRNA-25 expression quantity was higher than the near normal esophageal tissue quantity in the ESCC.The miRNA-143 expression quantity was lower than the near normal esophageal tissue quantity in the ESCC.The expression of miRNA-25 and miRNA-143 was obviously related to tumor clinical stage and lymph node metastasis（P＜0.05）,no correlation with the patients age,gender,tumor location and degree of tumor differentiation(P＞0.05).Conclusion:In the tumor tissue of the ESCC patients,the miRNA-25 expression quantity was obviously elevated,and the miRNA-143 expression quantity was obviously declined.miRNA-25 and miRNA-143 may be the potential tumor markers of ESCC.

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Memo

Memo:
西安交通大学医学院附属汉中3201医院院科研基金（编号：3201YK201509）
Last Update: 2018-01-29