|Table of Contents|

Real-world evidence based clinical research on management of hepatocellular carcinoma treated with TACE combined with Huaier Granules

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
741-746
Research Field:
Publishing date:

Info

Title:
Real-world evidence based clinical research on management of hepatocellular carcinoma treated with TACE combined with Huaier Granules
Author(s):
Dong DeshuoLiu Zhaoyu
Department of Radiology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China.
Keywords:
Huaier Granuleshepatocellular carcinomatranscatheter arterial chemoembolizationreal-world research
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2018.05.023
Abstract:
Objective:To evaluate the efficacy and safety of Huaier Granules combined with TACE in management of hepatocellular carcinoma (HCC),and to assess relevant factors affecting prognosis.Methods:A prospective real-world study was carried out in this research.During the period from September 2014 to December 2016,a total of 751 patients diagnosed with HCC were enrolled.Patients in experimental group were treated with TACE combined with Jin Ke Huaier Granules,and patients in control group were treated with TACE.The main observation indexes included progression free survival (PFS) and adverse reactions caused by Huaier Granules.Results:Up to June 2017,678 patients were eligible for evaluation,the overall median follow-up time was 282 days.The median progression free survival of 330 patients in experimental group was 381 days,while the median progression free survival of 348 patients in control group was 237 days.By using Kaplan-Meier analysis,the difference between the two groups was statistically significant (P=0.000 3).In experimental group,COX regression analysis showed the independent predictors of tumor progression after TACE were Child-Pugh grade and with or without portal vein tumor thrombus.During the follow-up time,different adverse effects occurred in 31 patients using Huaier Granules,which mainly included nausea and vomit.All the adverse effects relieved spontaneously without special treatment.Conclusion:TACE combined with Huaier Granules is effective and safe in management of hepatocellular carcinoma and is worthy of clinical promotion.

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