|Table of Contents|

Expression and clinical significance of cytokeratin 18,19 in prostate cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
737-740
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of cytokeratin 18,19 in prostate cancer
Author(s):
Zhang ChaoYin Bo
Urinary Surgery,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China.
Keywords:
prostate cancer (PCa)cytokeratin (CK)castration-resistant prostate cancer (CRPC)
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2018.05.022
Abstract:
Objective:To study the expression of cytokeratin (CK) 18 and CK19 in prostate cancer and further explore the clinical significance.Methods:Based on the risk stratification determined by Gleason score,65 cases of PCa were divided into high-risk group and low-risk group.The immunohistochemical staining was applied to detect the expression of CK18 and CK19 in PCa tissue samples.The further analysis was performed to determine the possible relationship between the expression of CK18 and CK19 with the clinical risk stratification of PCa.Results:The positive expression rate of CK18 was 31.4% (11/35) in high-risk group and 60.0% (15/25) in low-risk group (P=0.028).The positive expression rate of CK19 was 33.3% (11/33) in high-risk group and 65.5% (19/29) in low-risk group (P=0.011).The expression level of CK18 might be related to the time period of progression to the CRPC (castration-resistant prostate cancer) stage.The mean value of the time period of progression to the CRPC phase was 4.82 months in the positive expression group and 6.95 months in the negative expression group,respectively (t=2.501,P=0.018).Conclusion:In PCa,the downregulation of CK19 and CK18 was associated with higher clinical risk degree,and the downregulation of CK18 was associated with shortened time period of progression to CRPC.Our data may facilitate the diagnosis,treatment and prognosis assessment of prostate cancer.

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