|Table of Contents|

Efficacy and survival quality of synchronous radiotherapy and chemotherapy in patients with non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 04
Page:
527-529
Research Field:
Publishing date:

Info

Title:
Efficacy and survival quality of synchronous radiotherapy and chemotherapy in patients with non-small cell lung cancer
Author(s):
Feng Shujuan; Yang Wenlong
Department of Oncology,People's Hospital of Dengfeng,Henan Dengfeng 452470，China.
Keywords:
non-small cell lung cancer; concurrent radiotherapy and chemotherapy; sequential radiotherapy and chemotherapy
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2018.04.011
Abstract:
Objective:To investigate overall survival,safety and life qualities of chemotherapy with concurrent versus sequential radiotherapy for non-small cell lung cancer（NSCLC).Methods:Clinical data were retrospectively analysed on 60 NSCLC patients with brain metastasis,33 patients received whole brain radiotherapy with concomitant chemotherapy,and the other 27 patients received whole brain radiotherapy with sequential chemotherapy.The short-term efficacy,median survival time,adverse reaction and median PFS were compared between the two groups.Survival time was analysed between two groups with Kaplan-Meier method.Results：The disease control rate of radiotherapy with concomitant chemotherapy was significantly higher than that in concomitant chemoradiotherapy group（79% vs 56%，P＜0.05).Median survival time of chemotherapy with concurrent radiotherapy was 16.7 months,and group of chemotherapy with sequential radiotherapy was 12.3 months． The median survival time and PFS in concurrent chemotherapy and radiotherapy group were superior to those in radiotherapy with sequential chemotherapy group.The incidence of adverse reactions in concurrent chemotherapy and radiotherapy group was higher than that of radiotherapy with sequential chemotherapy group,but it is not statistically significant（P＞0.05).Conclusion：Compared with radiotherapy with sequential chemotherapy,concurrent radiotherapy and chemotherapy can significantly improve the short-term efficacy of non-small cell lung cancer patients with brain metastases and prolonged survival time.On the other hand,it will not affect the quality of life of patients more.

References:

[1]Emery A,Trifiletti DM,Romano KD,et al.More than just the number of brain metastases:Evaluating the impact of brain metastasis location and relative volume on overall survival after stereotactic radiosurgery［J］.World Neurosurgery,2017,99(1):111-117.
[2]Mu Haiyu,Shen Chunyan,Gao Yuqin.Progress in diagnosis and treatment of brian metastasis of lung cancer［J］.Oncology Progress,2012,10（2):129-135.［穆海玉,沈春燕,高雨琴.肺癌脑转移诊治策略进展［J］.癌症进展,2012,10(2):129-135.］
[3]Li Fenghu,Lu Bing,Fu Heyi,et al.Analysis of the significance of radiotherapy in 546 patients with stage IV non-small cell lung cancer［J］.Chin J Radiation Oncology,2012,21(2):122-125.
[4]Lopez Guerra JL，Gomez D，Zhuang Y，et al.Prognostic impact of radiation therapy to the primary tumor in patients with non-small cell lung cancer and oligometastasis at diagnosis［J］.Int J Radiat Oncol Biol Phys,2012,84（1）：61-67.
[5]Wu Delin,Zhao Zuoyin,Chen Meng,et al.Comparison of concurrent chemoradiotherapy and sequential chemoradiotherapy for locally advanced non small cell lung cancer［J］.Modern Oncology,2009,17（2):277-279.［吴德林,赵作银,陈猛,等.同步放化疗与序贯放化疗治疗局部晚期非小细胞肺癌疗效比较［J］.现代肿瘤医学,2009,17(2):277-279.］
[6]Kim ES,Hirsh V,Mok T,et al.Gefitinib versus docetaxel in previously treated non-small-cell lung cancer（INTEREST):A randomised phase Ⅲ trial［J］.Lancet,2008,372(9652):1809-1818.
[7]Zhang Ming,Ran Juntao,Wang Xiaohu,et al.Study of temozolomide and whole brian radiotherapy for non-small cell lung cancer patients with brain metastases［J］.Modern Oncology,2016,24(03):371-374.［张明，冉俊涛，王小虎，等.全脑放疗联合替莫唑胺治疗肺癌脑转移疗效观察［J］.现代肿瘤医学，2016,24(03):371-374.］
[8]Westeel V,Quoix E,Baudrin L,et al.Concurrent chemoradiation for elderly patients with locally advanced non-small-cell lung cancer:Still a controversial issue［J］.Aging Health,2016,8(2):119-122.
[9]Sun Wenze,Song Liping,Zhang Yingbing,et al.Comparative study of 93 cases of non small cell lung cancer treated by concurrent chemoradiotherapy combined with chemotherapy and sequential chemoradiotherapy［J］.Journal of Southern Medical University,2012,32(3):362-367.［孙文泽,宋丽萍,张莹冰,等.93例Ⅲ期非小细胞肺癌同步放化疗加巩固化疗与序贯放化疗的对比研究［J］.南方医科大学学报,2012,32(3):362-367.］
[10]Zhu Shendong,Duan Hongyan,Yu Qingrui.The clinical curative effect of concurrent chemoradiotherapy and sequential chemotherapy for stage Ⅲ non-small cell lung cancer［J］.Clinical Pulmonary Medicine Journal,2013,18（3):415-416.［祝沈冬,段宏燕,于清蕊.同步放化疗与序贯放化疗治疗Ⅲ期非小细胞肺癌的临床疗效比较［J］.临床肺科杂志,2013,18(3):415-416.］
[11]Mertsoylu H,Kse F,Sümbül AT,et al.Concurrent chemoradiotherapy with vinorelbine plus split-dose cisplatin may be an option in inoperable stage Ⅲ non-small cell lung cancer:A single-center experience［J］.Medical Science Monitor International Medical Journal of Experimental & Clinical Research,2015,21(7):661-666.
[12]Chen Ke,Pu Yongrui,Xie Guoming,et al.Concurrent chemoradiotherapy combined with chemotherapy and sequential chemotherapy in treatment of elderly patients with stage Ⅲ non-small cell lung cancer to compare the effects of［J］.Chinese Gerontology,2014,1(9):2420-2421.［陈科,朴勇瑞,谢国明,等.同步放化疗加巩固化疗与序贯放化疗治疗老年Ⅲ期非小细胞肺癌的疗效对比［J］.中国老年学,2014,1(9):2420-2421.］
[13]Villarrealgarza C,Del MD,Zavala DG,et al.Aggressive treatment of primary tumor in patients with non-small-cell lung cancer and exclusively brain metastases［J］.Clinical Lung Cancer,2013,14(1):6-13.
[14]Chen Dongmei,Meng Xiangying,Shen Ge,et al.Analysis of the incidence and risk factors of hippocampal metastasis in patients with lung cancer with brain metastasis［J］.Chinese Journal of Radiation Oncology,2017,26（2):138-143.［陈东梅,孟祥颖,申戈,等.肺癌脑转移患者海马转移发生率及其高危因素分析［J］.中华放射肿瘤学杂志,2017,26(2):138-143.］
[15]Brown PD,Ballman KV,Cerhan J,et al.N107C/CEC.3:A phase Ⅲ trial of post-operative stereotactic radiosurgery（SRS) compared with whole brain radiotherapy（WBRT) for resected metastatic brain disease［J］.International Journal of Radiation Oncology Biology Physics,2016,96(5):937.

Memo

Memo:
-
Last Update: 2017-12-29