|Table of Contents|

Effects of Apatinib in treatment of lung giant cell carcinoma:A case report and review of literature

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 04
Page:
530-533
Research Field:
Publishing date:

Info

Title:
Effects of Apatinib in treatment of lung giant cell carcinoma:A case report and review of literature
Author(s):
Li QiaozhenZhang CaijinWang Aimin
The 175th Hospital of the Chinese People's Liberation Army,Fujian Zhangzhou 363000,China.
Keywords:
lung giant cell carcinomapulmonary sarcomatoid carcinomaApatinibanti-angiogenesis therapy
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2018.04.012
Abstract:
Objective:To investigate the clinical characteristics,diagnosis and treatment of lung giant cell carcinoma.Methods:To report 1 case of lung giant cell carcinoma.Its clinical characteristics,imaging,pathological features and therapeutic effects were analyzed and related literatures were reviewed.Results:1 case of lung giant cell carcinoma patient who was hospitalized because of irritating cough and left chest stuffy pain for 3 months.Chest CT examination and pathological biopsy confirmed the diagnosis of giant cell carcinoma of the lung.The patient received docetaxel and cisplatin chemotherapy per three weeks.Her clinical symptoms slightly relieved after 2 cycles of chemotherapy and objective efficacy evaluation of therapies was stable disease.Objective efficacy evaluation of therapies was progressive disease after 4 cycles of chemotherapy.After anti-angiogenesis therapy with Apatinib,objective efficacy evaluation of therapies was still progressive disease.Conclusion:Lung giant cell carcinoma was very rare,which had a short survival time and poor prognosis.There was no generally accepted standard treatment.The patient received chemotherapy might be feasible to delay the progression of tumor and anti-angiogenesis therapy with Apatinib may be ineffective.

References:

[1]Krishnamurthy A,Vijayalakshmi N,Majhi U.A fatal case of pure giant cell carcinoma of the lung[J].J Cancer Res Ther,2011,7(3):363-365.
[2]Alasio TM,Sun W,Yang GC.Giant cell carcinoma of the lung impact of diagnosis and review of cytological features[J].Diagn Cytopathol,2007,35(9):555-559.
[3]Ishibashi H,Akamatsu H,Sunamori M,et al.Gingival metastasis of pulmonary pleomorphic carcinoma:Report of a case[J].Kyobu Geka,2005,58(5):410-414.
[4]Xu CC,Gui Q,Fu XN.Adenocarcinoma combined with giant cell carcinoma of the lung:A case report and review of literature[J].Cancer Research on Prevention and Treatment,2011,38(6):729-730.[徐澄澄,桂琦,付向宁.肺腺癌合并巨细胞癌1例及文献复习[J].肿瘤防治研究,2011,38(6):729-730.]
[5]Fishback NF,Travis WD,Moran CA,et al.Pleomorphic(spindle/giant cell) carcinoma of the lung.A clinicopathologic correlation of 78 cases[J].Cancer,1994,73(12):2936-2945.
[6]Rossi G,Cavazza A,Sturm N,et al.Pulmonary carcinomas with pleomorphic,sarcomatoid,or sarcomatous elements:A clinicopathologic and immunohistochemical study of 75 cases[J].Am J Surg Pathol,2003,27(3):311-324.
[7]Travis WD,Brambilla E,Müller-Hermelink HK,et al.World health organization classification of tumors:Pathology and genetics of tumors of the lung,pleura,thymus and heart [M].Lyon:IARC Press,2004:26-67.
[8]Kodama T,Miyazaki K,Satoh H,et al.Giant cell lung carcinoma in a man with acquired immunodeficiency syndrome[J].Med Oncol,2009,26(2):167-169.
[9]Oncale M,Kimbrell HZ,Barnhill M,et al.Antemortem diagnosis of likely giant cell carcinoma of the lung by pleural fluid cytology evaluation[J].Ochsner J,2015,15(2):196-199.
[10]Jiang WY,Fu XN,Liao YD,et al.Analysis of giant cell carcinoma of the lung:6 cases review[J].Journal of Clinical Pulmonary Medicine,2012,17(2):358.[江文洋,付向宁,廖永德,等.肺巨细胞癌6例分析[J].临床肺科杂志,2012,17(2):358.]
[11]Choi HS,Seol H,Heo IY,et al.Fine-needle aspiration cytology of pleomorphic carcinomas of the lung[J].Korean J Pathol,2012,46(6):576-582.
[12]Ito K,Oizumi S,Fukumoto S,et al.Clinical characteristics of pleomorphic carcinoma of the lung[J].Lung Cancer,2010,68(2):204-210.
[13]Rashid S,Rajan D,Jacob R,et al.Colonic metastases from pleomorphic carcinoma of the lung presenting as an ileocecal intussusception[J].Gastroenterol,2011,2011:137139.
[14]Ouziane I,Boutayeb S,Mrabti H,et al.Sarcomatoid carcinoma of the lung:A model of resistance of chemotherapy[J].N Am J Med Sci,2014,6(7):342-345.
[15]Schaefer IM,Sahlmann CO,Overbeck T,et al.Blastomatoid pulmonary carcinosarcoma:Report of a case with a review of the literature[J].BMC Cancer,2012,12:424.
[16]Weissferdt A,Moran CA.Malignant biphasic tumors of the lungs[J].Adv Anat Pathol,2011,18(3):179-189.
[17]Kim TS,Han J,Lee KS,et al.CT findings of surgically resected pleomorphic carcinoma of the lung in 30 patients[J].AJR Am J Roentgenol,2005,185(1):120-125.
[18]You Yonghao,Liu Rongting,Li Ming.Two cases report of giant cell carcinoma of the lung and literature review[J].Modern Oncology,2012,20(12):2641.[游永浩,刘荣婷,李鸣.肺巨细胞癌2例报告及文献复习[J].现代肿瘤医学,2012,20(12):2641.]
[19]Hiroshima K,Dosaka-Akita H,Usuda K,et al.Cytological characteristics of pulmonary pleomorphic and giant cell carcinomas[J].Acta Cytol,2011,55(2):173-179.
[20]Zhao ZL,Song N,Huang QY,et al.Clinicopathologic features of lung pleomorphic(spindle/giant cell) carcinoma-a report of 17 cases[J].Chin J Cancer,2007,26(2):183-188.
[21]Lin Y,Yang H,Cai Q,et al.Characteristics and prognostic analysis of 69 patients with pulmonary sarcomatoid carcinoma[J].Am J Clin Oncol,2016,39(3):215-222.
[22]Xiong WJ,Zhang XX,Huang MJ,et al.Outcomes of treatment of 32 cases of advanced or relapsed post-surgery pulmonary sarcomatoid carcinoma[J].J Sichuan Univ(Med Sci Edi),2014,45(2):320-323.[熊伟杰,张新星,黄媚娟,等.32例晚期及术后复发肺肉瘤样癌患者的治疗及生存分析[J].四川大学学报(医学版),2014,45(2):320-323.]
[23]Xu WJ,Huang C,Wang LC,et al.Characteristics and prognostic analysis of 47 patients with lung sarcomatoid carcinoma[J].Chinese Journal of Clinical Oncology,2008,35(18):1045-1049.[徐文静,黄纯,王柳春,等.47例肺肉瘤样癌的特征及预后因素分析[J].中国肿瘤临床,2008,35(18):1045-1049.]
[24]Italiano A,Cortot AB,Ilie M,et al.EGFR and KRAS status of primary sarcomatoid carcinomas of the lung:Implications for anti-EGFR treatment of a rare lung malignancy[J].Int J Cancer,2009,125(10):2479-2482.
[25]Venissac N,Pop D,Lassalle S,et al.Sarcomatoid lung cancer(spindle/giant cells):An aggressive disease[J]? J Thorac Cardiovasc Surg,2007,134(3):619-623.
[26]Vieira T,Duruisseaux M,Ruppert AM,et al.Pulmonary sarcomatoid carcinoma[J].Bull Cancer,2012,99(10):995-1001.
[27]Jiang X,Liu Y,Chen C,et al.The value of biomarkers in patients with sarcomatoid carcinoma of the lung:Molecular analysis of 33 cases[J].Clin Lung Cancer,2012,13(4):288-296.
[28]Nie XM,Bai CG,Sun QY,et al.Effects of gefitinib in treatment of sarcomatoid carcinoma of lung:A case report and literature review[J].Chin J Respir Crit Care Med,2012,11(2):172-174.[聂小蒙,白辰光,孙沁莹,等.吉非替尼治疗肺肉瘤样癌一例及文献复习[J].中国呼吸与危重监护杂志,2012,11(2):172-174.]
[29]Leone A,Graziano P,Gasbarra R,et al.Identification of EGFR mutations in lung sarcomatoid carcinoma[J].Int J Cancer,2011,128(3):732-735.
[30]Kaira K,Horie Y,Ayabe E,et al.Pulmonary pleomorphic carcinoma:A clinicopathological study including EGFR mutation analysis[J].J Thorac Oncol,2010,5(4):460-465.
[31]Ferrara N.Binding to the extracellular matrix and proteolytic processing:Two key mechanisms regulating vascular endothelial growth factor action[J].Mol Biol Cell,2010,21(5):687-690.
[32]Zheng X,Sun BC,Zhao XL,et al.Relationship between vasculogenic mimicry and epithelial-to-mesenchymal transition in pulmonary sarcomatoid carcinoma[J].Chinese Journal of Clinical Oncology,2013,40(8):431-433.[郑旭,孙保存,赵秀兰,等.肺肉瘤样癌中血管生成拟态的形成及其与上皮间充质转化的关系[J].中国肿瘤临床,2013,40(8):431-433.]
[33]Qin SK,Li J.Apatinib for clinical application,expert consensus for the treatment of gastric cancer[J].Chinese Clinical Oncology,2015,20(9):841-847.[秦叔逵,李进.阿帕替尼治疗胃癌的临床应用专家共识[J].临床肿瘤学杂志,2015,20(9):841-847.]

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Last Update: 2017-12-29