|Table of Contents|

Study on the correlation between FBN1/FBN2 gene methylation and esophageal carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 04
Page:
523-526
Research Field:
Publishing date:

Info

Title:
Study on the correlation between FBN1/FBN2 gene methylation and esophageal carcinoma
Author(s):
Zhang Jianhua1; Guo Qi1; Zhou Zhangjian2; Zhang Yi1
1.Department of Surgery,Xi'an Chest Hospital,Shaanxi Xi'an 710000,China;2.Medical Department of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China.
Keywords:
esophageal cancer; FBN1; FBN2; gene; methylation
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2018.04.010
Abstract:
Objective:This paper tested the Fibrillin-1（FBN1) and Fibrillin-2（FBN2) gene promoter methylation status in tumor tissue of esophageal cancer patients,to further explore the relationship between the methylation of these genes and esophageal cancer,to provide a theoretical basis for the study of tumor development.Methods：Methylation specific PCR（MSP) detection method was used to detect the methylation status of FBN1 and FBN2 gene promoter in 95 cases of esophageal cancer tissues and adjacent tissues specimens.Results：The methylation rate of FBN1 gene in esophageal cancer tissues and adjacent tissues were 86.3%（82/95) and 5.3%（5/95).The rates of FBN2 gene methylation were 82.1%（78/95) and 8.4%（8/95),the difference was statistically significant（P＜0.001).And the patients were divided into groups according to the degree of differentiation,TNM stage,gender and so on,there was no significant difference between the groups（P＞0.05).Conclusion:There is a very close relationship between the methylation of FBN1/FBN2 gene and esophageal cancer.The gene can be used as a potential tumor suppressor gene,and this study may provide a theoretical basis for the potential pathogenesis and treatment of esophageal cancer.

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Last Update: 2017-12-29