|Table of Contents|

Effects of arsenous acid in combination with ionizing radiation on proliferation,migration and invasion of hepatocellular carcinoma HepG2 cells

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 02
Page:
190-193
Research Field:
Publishing date:

Info

Title:
Effects of arsenous acid in combination with ionizing radiation on proliferation,migration and invasion of hepatocellular carcinoma HepG2 cells
Author(s):
Ye JiacaiHuang LaijiZhang XiupingDeng JinDing Yan
Radiotherapy Department,Tumour Hospital Affiliated to Guangzhou Medical College,Guangdong Guangzhou 510095,China.
Keywords:
arsenous acidionizing radiationhepatocellular carcinomaproliferationmigration and invasion
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2018.02.008
Abstract:
Objective:To investigate effects of arsenous acid in combination with ionizing radiation on proliferation,migration and invasion of hepatocellular carcinoma HepG2 cells.Methods:CCK-8 and EdU assay were used to detect the effects of ionizing radiation,arsenous acid and combination on proliferation of hepatocellular carcinoma HepG2 cells.Transwell assay was used to detect the effects of treatment described above on migration and invasion of HepG2 cells.Results:Compared with control group,ionizing radiation,arsenous acid and combination treatment decreased the ability of proliferation of HepG2 cells,the S phase cell proportion reduced.And the abilities of migration and invasion of HepG2 cells were inhibited.The influence of arsenous acid in combination with ionizing radiation was the most significantly.Conclusion:Arsenous acid in combination with ionizing radiation inhibit the abilities proliferation,migration and invasion of hepatocellular carcinoma HepG2 cells.

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Last Update: 2017-11-30