|Table of Contents|

The effect and function mechanism of Shugan Huazhuo Fang on malignant liver tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 01
Page:
62-65
Research Field:
Publishing date:

Info

Title:
The effect and function mechanism of Shugan Huazhuo Fang on malignant liver tumors
Author(s):
Ma Yunfeng1Yang Jun'en2
1.Tangshan Gongren Hospital Group Rehabilitation Hospital,Hebei Tangshan 063003,China;2.Tangshan Gongren Hospital,Hebei Tangshan 063000,China.
Keywords:
Shugan Huazhuo FangMHCsurvival timeMVDVEGF
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2018.01.016
Abstract:
Objective:To investigate the clinical efficacy and its mechanism of Shugan Huazhuo Fang on malignant liver tumor (MHC).Methods:120 patients with malignant liver tumors were randomly divided into control group and observation group.The control group was treated with conventional interventional therapy,based on the treatment of the control group,patients in the observation group added Shugan Huazhuo Fang,the changes of tumor necrosis and the level of alpha-fetoprotein (AFP) were compared,the microvessel density (MVD) and vascular endothelial growth factor (VEGF) horizontal changes,effective rate and living conditions were compared after 3 months.Results:Compared with the control group,the area of tumor necrosis was significantly decreased and the AFP negative conversion ratio was significantly higher than that of the control group.The survival rate was higher than that of the control group (P<0.05),MVD and VEGF were significantly decreased (P<0.05).Conclusion:Shugan Huazhuo Fang shows a good clinical therapeutic effect on MHC,and its mechanism may be related to the reduction of MVD count and VEGF levels in the tumor,the inhibition of tumor internal blood vessel formation and the reduction of blood supply.

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Memo

Memo:
河北省中医药管理局指导研究项目(编号:2016121)
Last Update: 2017-11-30