|Table of Contents|

Clinical analysis of 35 cases of intracerebral hemangiopericytomas prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 01
Page:
31-34
Research Field:
Publishing date:

Info

Title:
Clinical analysis of 35 cases of intracerebral hemangiopericytomas prognosis
Author(s):
Xue Yafei; Wu Yingxi; Zhao Lanfu; Lv Wenhai; Zhao Tianzhi; Wang Yuan; Chen Lei; He Shiming
Department of Neurosurgery，Tangdu Hospital of The Fourth Military Medical University，Shaanxi Xi'an 710038，China.
Keywords:
hemangiopericytomas; central nervous system; survival; recurrence; treatment; prognosis
PACS:
R739.91
DOI:
10.3969/j.issn.1672-4992.2018.01.008
Abstract:
Objective：To explore and summarize efficacy in treatment and prognosis of intracranial hemangiopericytomas (HPCs).Methods：Clinical data of 35 cases of HPCs in the central nervous system were analyzed retrospectively.All surgeries were performed under microscope and the critical factors which affect prognosis of HPCs were studied by statistical analysis.Results：The median survival for all patients was 82.4 months after date of diagnosis，with 1-year，5-year，10-year survival rates of 100%，93.8% and 72.4%，respectively.Thirteen patients had HPCs recurrence.The median time of recurrence was 65.4 months，with 1-year，5-year and 10-year progression-free survival rates of 99%，49%，31%.Three patients developed extracranial metastasis.Patients undergoing any form of adjuvant radiation treatment had no longer overall survival (P=0.22)，but had a significantly improved progression-free interval (P=0.04).Tumor characteristics associated with earlier recurrence included size ≥6 cm and sinus invasion.Conclusion：Surgeries combining adjuvant radiation with tumor resection appeared to inhibit tumor progression，but had no effect on overall survival.Greater extent of resection was related to increased overall survival (P<0.05).Anaplastic HPC was associated with reduced overall survival and with reduced recurrence interval (P<0.05).

References:

［1］Copeland WR，Link MJ，Stafford SL，et al.Single-fraction stereotactic radiosurgery of meningeal hemangiopericytomas［J］.J Neurooncol，2014，120(1)：95-102.
［2］Maekawa A，Kohashi K，Yamada Y，et al.A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component［J］.Neuropathology，2015，35(3)：260-265.
［3］Rutkowski MJ，Jian BJ，Bloch O，et al.Intracranial hemangiopericytoma：clinical experience and treatment considerations in a modern series of 40 adult patients［J］.Cancer，2012，118(6)：1628-1636.
［4］Zhou JL，Liu JL，Zhang J，et al.Thirty-nine cases of intracranial hemangiopericytoma and anaplastic hemangiopericytoma：a retrospective review of MRI features and pathological findings［J］.Eur J Radiol，2012，81(11)：3504-3510.
［5］Damodaran O，Robbins P，Knuckey N，et al.Primary intracranial haemangiopericytoma：comparison of survival outcomes and metastatic potential in WHO grade II and III variants［J］.J Clin Neurosci，2014，21(8)：1310-1314.
［6］Kumar N，Kumar R，Kapoor R，et al.Intracranial meningeal hemangiopericytoma：10 years experience of a tertiary care Institute［J］.Acta Neurochirurgica，2012，154(9)：1647-1651.
［7］Ecker RD，Marsh WR，Pollock BE，et al.Hemangiopericytoma in the central nervous system：treatment，pathological features，and long-term follow up in 38 patients［J］.J Neurosurg，2003，98(6)：1182-1187.
［8］Melone AG，Delia A，Santoro F，et al.Intracranial hemangiopericytoma our experience in 30 years：a series of 43 cases and review of the literature［J］.Word Neurosurg，2014，81(3-4)：556-562.
［9］Chen LF，Yang Y，Yu XG，et al.Multimodal treatment and management strategies for intracranial hemangiopericytoma［J］.J Clin Neurosci，2015，22(4)：718-725.
［10］Xu BT，Qi ST，Wang HX，et al.Clinical characteristics and treatment of intracranial hemangiopericytomas［J］.Chin J Neurosurg，2014，30(8)：792-795.
［11］Tian RF，Liu BY，Hao SY，et al.Prognostic analysis of recurrent hemangiopericytoma in the central nervous system［J］.Chin J Neurosurg，2013，29(1)：41-44.
［12］Ghia AJ，Allen PK，Mahajan A，et al.Intracranial hemangiopericytoma and the role of radiation therapy：a population based analysis［J］.Neurosurgery，2013，72(2)：203-209.
［13］Pang H，Yao Z，Ren Y，et al.Morphologic patterns and imaging features of intracranial hemangiopericytomas：a retrospective analysis［J］.Onco Targets Ther，2015，8：2169-2178.

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Last Update: 2017-11-30