|Table of Contents|

Analysis of EGFR gene mutation in non-small cell lung cancer in Shenyang Liaoning,China

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 01
Page:
35-39
Research Field:
Publishing date:

Info

Title:
Analysis of EGFR gene mutation in non-small cell lung cancer in Shenyang Liaoning,China
Author(s):
Zhang YingWang ZheYang Xianghong
Department of Pathology,Affiliated Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China.
Keywords:
non-small cell lung cancerepidermal growth factor receptorgene mutationEGFR-tyrosine kinase inhibitor
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2018.01.009
Abstract:
Objective:To investigate EGFR gene mutations in non-small cell lung cancers in Shenyang of Liaoning and to analyze the relationship of EGFR mutations with clinicopathologic features. Methods:Mutations of exons 18,19,20 and 21of the EGFR in 471 NSCLC patients in Shenyang of Liaoning were detected by PCR-Amplification Refratory Mutation System.Results:EGFR mutations were detected in 253 cases of 471 patients with NSCLC (53.7%).Mutations were mainly detected in exon 19del (42.3%) and exon 21 L858R(51.8%).The EGFR mutation rate of female patients(67.9%) was significantly higher than that of male patients(37.4%),and the difference was statistically significant(P=0.000).Moreover,the EGFR mutation rate was significantly higher in adenocarcinoma(57.2%) than other types(18.6%),and the difference was statistically significant(P=0.000).Conclusion:The EGFR mutations in NSCLC patients in Shenyang of Liaoning were more frequently found in females,adenocarcinoma patients,and the main types of mutations were exon 19del and exon 21 L858R mutation.

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Last Update: 2017-11-30