|Table of Contents|

The relationship between metformin induced autophagy and tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
985-987
Research Field:
Publishing date:

Info

Title:
The relationship between metformin induced autophagy and tumor
Author(s):
Gao Yan1; Xu Guifen2; Zhang Hua1
1.Department of Medical Oncology，Harbin Medical University Cancer Hospital，Heilongjiang Harbin 150000，China;2.Medical Insurance Section，the Fourth Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China.
Keywords:
metformin; autophagy; tumor
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2017.06.042
Abstract:
Metformin was the most widely used antidiabetic drug that belongs to the biguanide class.Metformin decreases hepatic glucose production via a mechanism requiring liver kinase B1,which controls the metabolic checkpoint.The effects of metformin on this pathway reduced protein synthesis and cell proliferation.These observations had given the impetus for many investigations on the role of metformin in the regulation of tumor cell proliferation,autophagy and apoptosis.In different tumors and tumor cell stages,effects of metformin induced autophagy on tumor development were different.There were numerous experiments committed to whether metformin can be used as an antitumor drug in clinical treatment.Metformin was expected to become a new antitumor drug or adjuvant drug.

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黑龙江省教育厅科学技术研究项目(编号:12541553)
Last Update: 2017-01-26